{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:21:03Z","timestamp":1791897663244,"version":"4.3.4"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"13","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S136898002100029X_as1\"><jats:title>Objective:<\/jats:title><jats:p>We examined whether folic acid (FA) supplementation prevented congenital hydrocephalus (CH) in more than 200 000 births in China.<\/jats:p><\/jats:sec><jats:sec id=\"S136898002100029X_as2\"><jats:title>Design:<\/jats:title><jats:p>A large population-based cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S136898002100029X_as3\"><jats:title>Setting:<\/jats:title><jats:p>All births at 20 complete gestational weeks, including live births, stillbirths and pregnancy terminations, and all structural birth defects regardless of gestational week were recorded. The prevalence of births with CH was classified by maternal characteristics and FA supplementation. CH was diagnosed in accordance with code 742.3 of the International Classification of Diseases, Ninth Revision, Clinical Modification, while non-neural tube defect (NTD) CH refers to CH without anencephaly (740), spina bifida (741) or encephalocele (742\u00b70).<\/jats:p><\/jats:sec><jats:sec id=\"S136898002100029X_as4\"><jats:title>Participants:<\/jats:title><jats:p>A total of 247 831 pregnant women who delivered with known outcomes were included.<\/jats:p><\/jats:sec><jats:sec id=\"S136898002100029X_as5\"><jats:title>Results:<\/jats:title><jats:p>A total of 206 cases of CH (0\u00b783 per 1000 births) and 170 cases of non-NTD CH (0\u00b769 per 1000 births) were recorded in the study. The prevalence of CH and non-NTD CH was higher in women in the no supplementation group than those in the FA supplementation group (0\u00b792 and 0\u00b772 <jats:italic>v<\/jats:italic>. 0\u00b775 and 0\u00b765 per 1000 births, respectively). FA supplementation during the periconceptional period significantly prevented CH (OR = 0\u00b729, 95 % CI 0\u00b712, 0\u00b769) and non-NTD CH (OR = 0\u00b734, 95 % CI 0\u00b712, 0\u00b797) in northern China, especially in a high-compliance group (\u2265 80 %).<\/jats:p><\/jats:sec><jats:sec id=\"S136898002100029X_as6\"><jats:title>Conclusions:<\/jats:title><jats:p>Periconceptional FA supplementation did not significantly prevent CH overall in the current study. However, in the north of China with common maternal folate insufficiency, there was some evidence.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s136898002100029x","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T04:03:49Z","timestamp":1611633829000},"page":"4238-4244","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Folic acid supplementation and risk for congenital hydrocephalus in China"],"prefix":"10.1017","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5844-8973","authenticated-orcid":false,"given":"Jufen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongwei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3220-6084","authenticated-orcid":false,"given":"Jianmeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"S136898002100029X_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq028"},{"key":"S136898002100029X_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13686"},{"key":"S136898002100029X_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70598-1"},{"key":"S136898002100029X_ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412001"},{"key":"S136898002100029X_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091510310"},{"key":"S136898002100029X_ref15","first-page":"180","article-title":"Prevalence analysis on congenital hydrocephalus in Chinese perinatal from 1996 to 2004","volume":"40","author":"Dai","year":"2006","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"S136898002100029X_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.03.005"},{"key":"S136898002100029X_ref12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2003.00478.x"},{"key":"S136898002100029X_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-017-0172-4"},{"key":"S136898002100029X_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23368"},{"key":"S136898002100029X_ref14","first-page":"1039","article-title":"Global hydrocephalus epidemiology and incidence: systematic review and meta-analysis","volume":"130","author":"Dewan","year":"2018","journal-title":"J Neurosurg"},{"key":"S136898002100029X_ref16","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-017-1603-2"},{"key":"S136898002100029X_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980007246786"},{"key":"S136898002100029X_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31819e64a7"},{"key":"S136898002100029X_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18776226"},{"key":"S136898002100029X_ref19","first-page":"465","article-title":"Analysis of L1CAM gene mutation in pedigrees with X-linked genetic hydrocephalus","volume":"36","author":"Hu","year":"2019","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za 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