{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:59:45Z","timestamp":1747173585314,"version":"3.40.5"},"reference-count":80,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980021004407_as1\"><jats:title>Objective:<\/jats:title><jats:p>To investigate the association between serum vitamin D (25-hydroxy-cholecalciferol) (25(OH)D) concentrations and cognitive impairment in older adults living in Southern Brazil.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980021004407_as2\"><jats:title>Design:<\/jats:title><jats:p>Cross-sectional analysis using data from the second follow-up wave of the populational-based EpiFloripa Aging Cohort Study was collected in 2013\u20132014.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980021004407_as3\"><jats:title>Setting:<\/jats:title><jats:p>Cognitive impairment was evaluated using the Mini-Mental State Examination (MMSE). Blood samples were collected to measure serum vitamin D concentrations using a chemiluminescent microparticle immunoassay. Vitamin D concentrations were distributed in quartiles (Q1: 4\u00b70\u201320\u00b77 ng\/ml; Q2: 20\u00b78\u201326\u00b76 ng\/ml; Q3: 26\u00b77\u201332\u00b70 ng\/ml and Q4: 32\u00b71\u201360\u00b71 ng\/ml), and its association with cognitive impairment was tested by crude and adjusted logistic regression (sociodemographic, behavioural and health aspects) using Q4 as a reference group.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980021004407_as4\"><jats:title>Participants:<\/jats:title><jats:p>200 men and 371 women aged 60 years or older participated in this study.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980021004407_as5\"><jats:title>Results:<\/jats:title><jats:p>The prevalence of probable cognitive impairment was 21\u00b77 %. Those without cognitive impairment had a higher mean of vitamin D serum concentrations (26\u00b78 <jats:italic>v<\/jats:italic>. 24\u00b76, <jats:italic>P<\/jats:italic> = 0\u00b7014). In the crude analysis, only individuals in Q2 of vitamin D presented an increased risk for probable cognitive impairment compared with Q4 (highest quartile) (OR 2\u00b765, 95 % CI 1\u00b746, 4\u00b781), remaining significant in the adjusted analysis (OR 6\u00b704, 95 % CI 2\u00b778, 13\u00b713). While Q1 (lowest quartile) was not associated in the crude analysis, but when adjusted, an increased risk of cognitive impairment was observed.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980021004407_as6\"><jats:title>Conclusion:<\/jats:title><jats:p>The lowest quartile of vitamin D was directly associated with probable cognitive impairment in older adults in Southern Brazil. More studies are needed to investigate whether maintaining adequate serum levels may represent a significant factor in preventing age-related neurological disorders as well as to verify the need for new cutoff points for this age group.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980021004407","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T07:49:10Z","timestamp":1635148150000},"page":"2507-2516","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Association between lower serum vitamin D (25-hydroxy-cholecalciferol) concentrations and cognitive impairment in older adults: data from a populational-based cohort study in a middle-income country"],"prefix":"10.1017","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4825-6729","authenticated-orcid":false,"given":"Lu\u00edsa 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