{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:26:42Z","timestamp":1759883202916,"version":"build-2065373602"},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":181,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1368980025100451_as1\">\n\t    <jats:title>Objective:<\/jats:title>\n\t    <jats:p>To (1) determine how serum fatty acid (FA) levels differ by developmental stage, (2) quantify associations between perinatal HIV-related factors and PUFA levels and (3) examine the heterogeneity of these associations by developmental stage.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1368980025100451_as2\">\n\t    <jats:title>Design:<\/jats:title>\n\t    <jats:p>Cross-sectional secondary analysis of baseline data from two prospective cohorts.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1368980025100451_as3\">\n\t    <jats:title>Setting:<\/jats:title>\n\t    <jats:p>Kampala, Uganda.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1368980025100451_as4\">\n\t    <jats:title>Participants:<\/jats:title>\n\t    <jats:p>243 children (6\u201310 years old) and 383 adolescents (11\u201318 years old) were recruited at Kawaala Health Center based on perinatal HIV status. Youth (children and adolescents) were classified as: those with perinatal HIV infection (PHIV: <jats:italic>n<\/jats:italic> 212), those perinatally HIV exposed but remained uninfected (HEU: <jats:italic>n<\/jats:italic> 211) and those perinatally HIV unexposed and uninfected (HUU: <jats:italic>n<\/jats:italic> 203).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1368980025100451_as6\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>Adolescents had lower <jats:italic>n<\/jats:italic>-6 and <jats:italic>n<\/jats:italic>-3 PUFA levels than children, and among adolescents, these levels increased with age. Relative to children HUU, children PHIV had a higher triene:tetraene ratio and 20:3<jats:italic>n<\/jats:italic>-9 (indicators of essential fatty acid deficiency (EFAD)). Adolescents PHIV <jats:italic>v<\/jats:italic>. HUU had lower 20:5<jats:italic>n<\/jats:italic>-3 levels. When considering <jats:italic>in utero<\/jats:italic>\/peripartum antiretroviral therapy (IPA) exposure, the FA profile was indicative of EFAD for youth PHIV with (a) no IPA exposure and (b) combination IPA exposure, whereas non-nucleoside RT inhibitor+nucleoside RT inhibitor exposure was associated with a favourable FA profile among youth PHIV and HEU (all <jats:italic>P<\/jats:italic> &lt; 0\u00b705).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1368980025100451_as7\">\n\t    <jats:title>Conclusion:<\/jats:title>\n\t    <jats:p>In this sample, perinatal HIV status was associated with low PUFA levels, and these associations varied by developmental stage and IPA exposure type. Future research should elucidate the contribution of IPA exposure type to EFAD and the implications of these differences on growth and cognitive development.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s1368980025100451","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T02:10:41Z","timestamp":1751335841000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Associations between perinatal HIV-related risk factors and select serum PUFA levels among Ugandan children and adolescents"],"prefix":"10.1017","volume":"28","author":[{"given":"Vanessa N.","family":"Cardino","sequence":"first","affiliation":[{"name":"Michigan State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selin","family":"Sergin","sequence":"additional","affiliation":[{"name":"Michigan State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah K.","family":"Zalwango","sequence":"additional","affiliation":[{"name":"Kampala Capital City Authority"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8875-3239","authenticated-orcid":false,"given":"Jenifer I.","family":"Fenton","sequence":"additional","affiliation":[{"name":"Michigan State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amara E.","family":"Ezeamama","sequence":"additional","affiliation":[{"name":"Michigan State University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"S1368980025100451_ref41","doi-asserted-by":"publisher","DOI":"10.1093\/heapro\/daad097"},{"key":"S1368980025100451_ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80247-8"},{"key":"S1368980025100451_ref48","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001149"},{"key":"S1368980025100451_ref3","first-page":"97","article-title":"EPA\/DHA: a review of clinical use and efficacy","volume":"2","author":"Elgar","year":"2022","journal-title":"Nutr Med J"},{"key":"S1368980025100451_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003324"},{"key":"S1368980025100451_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-012-0677-0"},{"key":"S1368980025100451_ref7","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061268"},{"key":"S1368980025100451_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/2156587213488788"},{"key":"S1368980025100451_ref35","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf5103"},{"key":"S1368980025100451_ref49","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-016-0115-x"},{"key":"S1368980025100451_ref6","doi-asserted-by":"publisher","DOI":"10.3390\/nu15081933"},{"key":"S1368980025100451_ref44","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020356"},{"key":"S1368980025100451_ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3820"},{"key":"S1368980025100451_ref21","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2018.1560768"},{"key":"S1368980025100451_ref37","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D000547"},{"key":"S1368980025100451_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneb.2023.05.030"},{"key":"S1368980025100451_ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-020-08669-7"},{"key":"S1368980025100451_ref31","doi-asserted-by":"publisher","DOI":"10.1186\/s13690-019-0332-6"},{"key":"S1368980025100451_ref9","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002689"},{"key":"S1368980025100451_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115595980"},{"key":"S1368980025100451_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2015.12.001"},{"key":"S1368980025100451_ref45","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.115691"},{"key":"S1368980025100451_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2017.01.012"},{"key":"S1368980025100451_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1026"},{"key":"S1368980025100451_ref28","unstructured":"28. 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