{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:29:12Z","timestamp":1785421752589,"version":"3.56.0"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"unspecified","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1368980026101827_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate whether taste perception of two artificial sweeteners\u2014aspartame and neohesperidin dihydrochalcone (NHDC)\u2014is causally associated with the risk of site-specific cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1368980026101827_as2\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A two-sample Mendelian randomisation (MR) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1368980026101827_as3\">\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Genetic instruments for taste perception (6 for aspartame; 13 for NHDC) were obtained from a genome-wide association study (GWAS) of Australian adolescents, and cancer outcome data were sourced from publicly available GWAS datasets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1368980026101827_as4\">\n                    <jats:title>Participants:<\/jats:title>\n                    <jats:p>\n                      Genetic data for taste perception from 1757 Australian adolescents and genetic data for cancers from large-scale GWAS cohorts, including UK Biobank (\n                      <jats:italic>n<\/jats:italic>\n                      500 000) and FinnGen (\n                      <jats:italic>n<\/jats:italic>\n                      500 000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1368980026101827_as5\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A one\n                      <jats:sc>sd<\/jats:sc>\n                      increase in the genetically predicted perceived intensity of NHDC was associated with an increased risk of male genital cancer (OR = 1\u00b711, 95 % CI: 1\u00b704, 1\u00b719) and prostate cancer (OR = 1\u00b703, 95 % CI: 1\u00b701, 1\u00b708) based on FinnGen data. These associations persisted after multivariable MR adjustment for glucose and aspartame perception but were not replicated in the UK Biobank. A weak protective association between aspartame perception and cervical cancer (OR = 0\u00b7998, 95 % CI: 0\u00b7997, 0\u00b7999) was observed, but this attenuated to null in sensitivity analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1368980026101827_as6\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study found no compelling evidence that perception of aspartame or NHDC during adolescence causally influences later-life cancer risk. The findings highlight the importance of evaluating individual artificial sweeteners separately in future research examining potential health effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1368980026101827","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:47:25Z","timestamp":1768204045000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the relationship between taste perception of artificial sweeteners and cancer risk"],"prefix":"10.1017","volume":"29","author":[{"given":"Daisy C. P.","family":"Crick","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rqy9422","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Bioscience, The University of Queensland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5535-2199","authenticated-orcid":false,"given":"Liang-Dar","family":"Hwang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00rqy9422","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Molecular Bioscience, The University of Queensland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"S1368980026101827_ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1347724"},{"key":"S1368980026101827_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/B978-008045382-8.00077-0"},{"key":"S1368980026101827_ref20","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02333-9"},{"key":"S1368980026101827_ref39","first-page":"e07595","article-title":"Re-evaluation of neohesperidine dihydrochalcone (E 959) as a food additive","volume":"20","author":"Younes","year":"2022","journal-title":"EFSA J"},{"key":"S1368980026101827_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.02.063"},{"key":"S1368980026101827_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2022.102201"},{"key":"S1368980026101827_ref14","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040501"},{"key":"S1368980026101827_ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01534-4"},{"key":"S1368980026101827_ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0255-x"},{"key":"S1368980026101827_ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00092-5"},{"key":"S1368980026101827_ref40","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020444"},{"key":"S1368980026101827_ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-021-00725-y"},{"key":"S1368980026101827_ref12","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8711"},{"key":"S1368980026101827_ref26","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3034"},{"key":"S1368980026101827_ref44","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02953"},{"key":"S1368980026101827_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2024.06.008"},{"key":"S1368980026101827_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2395"},{"key":"S1368980026101827_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291720005127"},{"key":"S1368980026101827_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv080"},{"key":"S1368980026101827_ref28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007081"},{"key":"S1368980026101827_ref45","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29427"},{"key":"S1368980026101827_ref31","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy163"},{"key":"S1368980026101827_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-022-02993-x"},{"key":"S1368980026101827_ref38","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddad043"},{"key":"S1368980026101827_ref11","first-page":"89","article-title":"The effect of aspartame administration on oncogene and suppressor gene expressions","volume":"21","author":"Gombos","year":"2007","journal-title":"In Vivo"},{"key":"S1368980026101827_ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120758"},{"key":"S1368980026101827_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00341-8"},{"key":"S1368980026101827_ref35","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy262"},{"key":"S1368980026101827_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-014-0818-5"},{"key":"S1368980026101827_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz043"},{"key":"S1368980026101827_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60269-X"},{"key":"S1368980026101827_ref30","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.21965"},{"key":"S1368980026101827_ref2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13061957"},{"key":"S1368980026101827_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18236"},{"key":"S1368980026101827_ref43","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys176"},{"key":"S1368980026101827_ref36","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2015.42"},{"key":"S1368980026101827_ref46","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjs070"},{"key":"S1368980026101827_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg070"},{"key":"S1368980026101827_ref47","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980022001598"},{"key":"S1368980026101827_ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003950"},{"key":"S1368980026101827_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08077.x"},{"key":"S1368980026101827_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2019.112579"},{"key":"S1368980026101827_ref34","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000559"},{"key":"S1368980026101827_ref5","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-22-0392"},{"key":"S1368980026101827_ref32","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0099-7"},{"key":"S1368980026101827_ref10","unstructured":"10. Joint FAO\/WHO Expert Committee on Food Additives (2009) Evaluation of Certain Food Additives. World Health Organization Technical Report Series No. 952, pp. 1\u2013208. Geneva: World Health Organization."},{"key":"S1368980026101827_ref19","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO05756A"}],"container-title":["Public Health Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1368980026101827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:14:27Z","timestamp":1784272467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1368980026101827\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"alternative-id":["S1368980026101827"],"URL":"https:\/\/doi.org\/10.1017\/s1368980026101827","relation":{},"ISSN":["1368-9800","1475-2727"],"issn-type":[{"value":"1368-9800","type":"print"},{"value":"1475-2727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e18"}}