{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:39:21Z","timestamp":1761057561612},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2002,6,14]],"date-time":"2002-06-14T00:00:00Z","timestamp":1024012800000},"content-version":"unspecified","delay-in-days":74,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsc Microanal"],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p>Modulation of lymphocyte flow in the lymphatic compartment \nof the lymph node may serve, in part, to promote lymphocyte \nsensitization during an antigenic challenge. This study was \nundertaken to show where this might occur by examining the \nstructural relationships of the intranodal lymphatic pathways, \nblood vessels, and connective tissue support with respect to \nlymphocyte and lymph flow. Differently stained plastic resins \nwere injected into the blood vessels and lymphatics of the \nsubmandibular lymph node and visualized with a confocal laser \nscanning microscope. The specimens were corroded to study the \nthree-dimensional cast structures by scanning electron microscopy. \nAlkali digestion was also used to prepare the reticular fiber \nnetwork in the lymph node for scanning electron microscopic \nexamination. At the hilus of the node, two to three arteries \ngave off arterioles running in medullary cords towards the cortex. \nThe medullary cords, the periphery of the deep cortex, and the \nperifollicular zones had dense capillary networks. In contrast, \nthe center of the follicle and the center of the deep cortex \nwere less highly vascularized. High-endothelial venules were \nrestricted to the perifollicular zone and the periphery of the \ndeep cortex. At the cortico-medullary boundary, they abruptly \ntransformed into medullary venules with a normal endothelium. \nThe marginal sinus of the lymph node was crossed by thick reticular \nfibers that arose from the inner sheets of the capsule. The \nlymph pathway went through the marginal sinus, into the trabecular \nsinus, to the cortical perifollicular sinus, the dense lymphatic \nsinus around the deep cortex, and finally into the medullary \nsinus. At present, the exact functional significance of the \ncomplex lymph node lymphatic architecture is not clear. However, \nthe highly organized structural organization may play a significant \nrole in regulating and directing lymphocyte flow to facilitate \nantigen presentation.<\/jats:p>","DOI":"10.1017\/s1431927601020049","type":"journal-article","created":{"date-parts":[[2002,11,13]],"date-time":"2002-11-13T23:28:04Z","timestamp":1037230084000},"page":"116-133","source":"Crossref","is-referenced-by-count":12,"title":["Structural Aspects of the Lymphocyte Traffic in Rat \nSubmandibular Lymph Node"],"prefix":"10.1093","volume":"8","author":[{"given":"Shigenori","family":"Okada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph M.","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedhossein","family":"Aharinejad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean E.","family":"Schraufnagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,6,14]]},"container-title":["Microscopy and Microanalysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1431927601020049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T21:02:40Z","timestamp":1676408560000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mam\/article\/8\/2\/116\/6905670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["S1431927601020049"],"URL":"https:\/\/doi.org\/10.1017\/s1431927601020049","relation":{},"ISSN":["1431-9276","1435-8115"],"issn-type":[{"value":"1431-9276","type":"print"},{"value":"1435-8115","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}