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After polishing the dentin surfaces, three groups were established: (1) untreated dentin (UD), (2) 37% phosphoric acid application for 15 s (partially demineralized dentin\u2014PDD), and (3) 10% phosphoric acid for 12 h at 25\u00b0 C (totally demineralized dentin\u2014TDD). Five different remineralizing solutions were used: chlorhexidine (CHX), artificial saliva (AS), phosphate solution (PS), ZnCl<jats:sub>2<\/jats:sub>, and ZnO. Wettability (contact angle), \u03b6 potential and Raman spectroscopy analysis were determined on dentin surfaces. Demineralization of dentin resulted in a higher contact angle. Wettability decreased after immersion in all solutions. \u03b6 potential analysis showed dissimilar performance ranging from \u22126.21 mV (TDD + AS) up to 3.02 mV (PDD + PS). Raman analysis showed an increase in mineral components after immersing the dentin specimens, in terms of crystallinity, mineral content, and concentration. This confirmed the optimal incorporation and deposition of mineral on dentin collagen. Organic content reflected scarce changes, except in TDD that appeared partially denatured. Pyridinium, as an expression of cross-linking, appeared in all spectra except in specimens immersed in PS.<\/jats:p>","DOI":"10.1017\/s1431927613013639","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T13:26:38Z","timestamp":1382707598000},"page":"245-256","source":"Crossref","is-referenced-by-count":16,"title":["Surface Microanalysis and Chemical Imaging of Early Dentin Remineralization"],"prefix":"10.1093","volume":"20","author":[{"given":"Manuel","family":"Toledano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Cabello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel Cabrerizo","family":"V\u00edlchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel 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