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This study aimed to investigate the adaptations in MTJ morphology of mdx mice in the tibialis anterior muscle. Male mice (<jats:italic>n<\/jats:italic> = 24) were divided into Control\u2014C57bl\/10 and mdx\u2014C57bl\/10<jats:sup>mdx<\/jats:sup> (Duchenne muscular dystrophy experimental model). In the mdx group, centralized nuclei with a large area and greater deposition of type III collagen (fibrosis) were observed. Also, shorter sarcomeres and sarcoplasmatic projections of MTJ were observed. 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