{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:19:58Z","timestamp":1793380798195,"version":"4.5.0"},"reference-count":53,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"unspecified","delay-in-days":105,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["J Radiother Pract"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1460396924000037_as1\">\n\t    <jats:title>Introduction:<\/jats:title>\n\t    <jats:p>Radiation dermatitis (RD) is a frequent toxicity during radiotherapy (RT) for head and neck cancer (HNC). We report the first use of KeraStat\u00ae Cream (KC), a topical, keratin-based wound dressing, in patients with HNC receiving RT.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1460396924000037_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>This pilot study randomized HNC patients treated with definitive or postoperative RT (\u226560 Gy) to KC or standard of care (SOC), applied at least twice daily during and for 1-month after RT. Outcomes of interest included adherence to the assigned regimen (at least 10 applications per week of treatment), clinician- and patient-reported RD, and skin-related quality of life.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1460396924000037_as3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>24 patients were randomized and completed the study. Most patients had stage III-IV disease and oropharynx cancer. Median RT dose was 68 Gy; the bilateral neck was treated in 19 patients, and 18 patients received concurrent chemotherapy. Complete adherence was observed in 7\/12 (SOC) vs. 10\/12 (KC, <jats:italic>p<\/jats:italic> = 0.65). \u00a0Adherence by patient-week was 61\/68 versus 64\/67, respectively (<jats:italic>p<\/jats:italic> = 0.20). No differences in RD were observed between groups.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1460396924000037_as4\">\n\t    <jats:title>Conclusion:<\/jats:title>\n\t    <jats:p>A randomized trial of KC versus SOC in HNC patients treated with RT is feasible with good adherence to study agent. An adequately powered randomized study is warranted to test the efficacy of KC in reducing RD.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s1460396924000037","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T10:03:24Z","timestamp":1713175404000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Keratin-based topical cream for radiation dermatitis during head and neck radiotherapy: a randomised, open-label pilot study"],"prefix":"10.1017","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-9753","authenticated-orcid":false,"given":"Ryan T","family":"Hughes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly J","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart A","family":"Frizzell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M","family":"Greven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Porosnicu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-1558","authenticated-orcid":false,"suffix":"Jr","given":"Thomas W","family":"Lycan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke R","family":"Burnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M","family":"Winkfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"S1460396924000037_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-2739-4_5"},{"key":"S1460396924000037_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13371"},{"key":"S1460396924000037_ref16","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2014.23.Sup2.S28"},{"key":"S1460396924000037_ref21","doi-asserted-by":"publisher","DOI":"10.1188\/20.ONF.E225-E236"},{"key":"S1460396924000037_ref9","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S188655"},{"key":"S1460396924000037_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.02.047"},{"key":"S1460396924000037_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.01.010"},{"key":"S1460396924000037_ref31","unstructured":"31. Hurt, J , Burnett, L. Keratin-based Biomaterial Significantly Attenuates Cellular Injury Responses Following UVB Exposure; 2014. https:\/\/staging.abstracts.biomaterials.org\/data\/papers\/2014\/0332-000595.pdf. 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Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e11"}}