{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:41:13Z","timestamp":1791394873091,"version":"4.3.3"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int. J. Neuropsychopharm."],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1017\/s1461145709991088","type":"journal-article","created":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T11:27:54Z","timestamp":1262690874000},"page":"1193-1205","source":"Crossref","is-referenced-by-count":25,"title":["Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective \u03b12A-adrenoceptor antagonism"],"prefix":"10.1093","volume":"13","author":[{"given":"Jason M.","family":"Dwyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Platt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey J.","family":"Sukoff Rizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine M.","family":"Pulicicchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Wantuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Cummons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Leventhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey N.","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Kowal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shendi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Johannes R.","family":"Rajarao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam D.","family":"Shilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Butera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Resnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Rosenzweig-Lipson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee E.","family":"Schechter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad E.","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"S1461145709991088_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0093-5"},{"key":"S1461145709991088_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.09.006"},{"key":"S1461145709991088_ref040","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.11.016"},{"key":"S1461145709991088_ref009","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2001.0857"},{"key":"S1461145709991088_ref008","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.1.187"},{"key":"S1461145709991088_ref039","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300418"},{"key":"S1461145709991088_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90196-2"},{"key":"S1461145709991088_ref038","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1124\/mol.51.1.36","volume":"51","author":"Sallinen","year":"1997","journal-title":"Molecular Pharmacology"},{"key":"S1461145709991088_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(99)00034-7"},{"key":"S1461145709991088_ref037","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0710-6"},{"key":"S1461145709991088_ref005","doi-asserted-by":"publisher","DOI":"10.1053\/scnp.2001.21837"},{"key":"S1461145709991088_ref036","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/sj.npp.1300954","volume":"31","author":"Rizk","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"S1461145709991088_ref004","doi-asserted-by":"publisher","DOI":"10.1177\/026988110201600403"},{"key":"S1461145709991088_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0896(95)00157-3"},{"key":"S1461145709991088_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.11.006"},{"key":"S1461145709991088_ref002","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.20.2433"},{"key":"S1461145709991088_ref034","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02553-7"},{"key":"S1461145709991088_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2004.11.001"},{"key":"S1461145709991088_ref033","first-page":"27","author":"Platt","year":"2008","journal-title":"Current Protocols in Neuroscience"},{"key":"S1461145709991088_ref032","volume-title":"Rat Brain in Stereotactic Coordinates","author":"Paxinos","year":"1986"},{"key":"S1461145709991088_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(98)00802-4"},{"key":"S1461145709991088_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2006.05.004"},{"key":"S1461145709991088_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00598-5"},{"key":"S1461145709991088_ref042","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3181\/00379727-95-23345","volume":"95","author":"Siegmund","year":"1957","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"S1461145709991088_ref028","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.109728"},{"key":"S1461145709991088_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(03)00080-7"},{"key":"S1461145709991088_ref026","doi-asserted-by":"publisher","DOI":"10.1126\/science.2823383"},{"key":"S1461145709991088_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)01447-P"},{"key":"S1461145709991088_ref024","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.01.007"},{"key":"S1461145709991088_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2003.09.020"},{"key":"S1461145709991088_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00175-2"},{"key":"S1461145709991088_ref021","doi-asserted-by":"publisher","DOI":"10.1038\/46040"},{"key":"S1461145709991088_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00565-4"},{"key":"S1461145709991088_ref050","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000044188.67442.9d"},{"key":"S1461145709991088_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2004.04.040"},{"key":"S1461145709991088_ref018","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.054544"},{"key":"S1461145709991088_ref049","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90801-7"},{"key":"S1461145709991088_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2003.12.016"},{"key":"S1461145709991088_ref048","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244910"},{"key":"S1461145709991088_ref016","volume-title":"Alpha-2 adrenoceptors regulate adult hippocampal neurogenesis and accelerate the effects of chronic antidepressant treatment on gene expression, neurogenesis and behavior, 122.8\/A8","author":"Fernandes","year":"2008"},{"key":"S1461145709991088_ref047","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.063560"},{"key":"S1461145709991088_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(94)00093-F"},{"key":"S1461145709991088_ref046","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1476-5381.1993.tb13623.x","volume":"109","author":"van Veldhuizen","year":"1993","journal-title":"British Journal of Pharmacology"},{"key":"S1461145709991088_ref014","doi-asserted-by":"publisher","DOI":"10.1002\/jps.3030460322"},{"key":"S1461145709991088_ref045","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1161\/01.HYP.27.3.449","volume":"27","author":"Tavares","year":"1996","journal-title":"Hypertension"},{"key":"S1461145709991088_ref013","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0022-5347(25)00278-2","volume":"241","author":"Dennis","year":"1987","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"S1461145709991088_ref044","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130418"},{"key":"S1461145709991088_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00052-0"},{"key":"S1461145709991088_ref043","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(95)00148-L"},{"key":"S1461145709991088_ref041","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.4.590"}],"container-title":["The International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/13\/9\/1193\/2038743\/13-9-1193.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T13:17:42Z","timestamp":1739711862000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article-lookup\/doi\/10.1017\/S1461145709991088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,5]]},"references-count":50,"journal-issue":{"issue":"09","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S1461145709991088"],"URL":"https:\/\/doi.org\/10.1017\/s1461145709991088","relation":{},"ISSN":["1461-1457","1469-5111"],"issn-type":[{"value":"1461-1457","type":"print"},{"value":"1469-5111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,5]]}}}