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Intraperitoneal administration of a non-selective [meta-chlorophenylpiperazine (m-CPP) 0.1\u20133 mg\/kg], preferential [S-2-(6-chloro-5-fluoroindol-1-yl)-1-methylethylamine, Ro60-0175, 0.1\u20133 mg\/kg] or selective [(7bR,10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole, WAY163909, 0.3\u201310 mg\/kg] 5-HT2C agonists enhanced oral bouts in naive rats. The 5-HT2C inverse agonists SB206553 [1\u201320 mg\/kg; 5-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole] and S32006 [1\u201320 mg\/kg; N-pyridin-3-yl-1,2-dihydro-3H-benzo[e]indole-3-carboxamide], but not the 5-HT2C antagonist SB243213 [1\u201310 mg\/kg; 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline], likewise dose-dependently enhanced oral movements. The effects induced by preferential 5-HT2C agonists and inverse agonists, but not by the cholinomimetic drug pilocarpine (5 mg\/kg), were abolished by SB243213 underpinning its specificity. S32006-induced oral bouts was unaffected by the 5,7-dihydroxytryptamine lesions of 5-HT neurons. Nigrostriatal dopaminergic lesions potentiated oral effects induced by the agonists Ro60-0175 (3 mg\/kg) and WAY163909 (1 mg\/kg), but not by the inverse agonist SB206553 (10 mg\/kg). The effect of Ro60-0175 in dopamine-lesioned rats was suppressed by SB243213. These data show that 5-HT2C agonists and full inverse agonists (but not neutral antagonists) perturb oral activity in rodents, paralleling studies of common antidepressant, anxiolytic and antipsychotic properties. The differential sensitivity of their actions to depletion of dopamine suggests recruitment of different contrasting neural mechanisms in the basal ganglia.<\/jats:p>","DOI":"10.1017\/s1461145712000417","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T10:11:37Z","timestamp":1336039897000},"page":"593-606","source":"Crossref","is-referenced-by-count":27,"title":["Serotonin2C ligands exhibiting full negative and positive intrinsic activity elicit purposeless oral movements in rats: distinct effects of agonists and inverse agonists in a rat model of Parkinson's disease"],"prefix":"10.1093","volume":"16","author":[{"given":"Sylvia","family":"Navailles","sequence":"first","affiliation":[{"name":"Universit\u00e9 Victor Segalen Bordeaux 2, Centre National de la Recherche Scientifique-Unit\u00e9 Mixte de Recherche 5293, Bordeaux Cedex, 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