{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:37:20Z","timestamp":1792715840365,"version":"4.5.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The present study was designed to investigate the effect of pharmacological inhibition of endocannabinoid degradation on behavioural actions of the dopamine D2\/D3 receptor agonist quinpirole in male C57Bl\/6J mice. In addition, we studied the effects of endocannabinoid degradation inhibition on both cocaine-induced psychomotor activation and behavioural sensitization. We analysed the effects of inhibition of the two main endocannabinoid degradation enzymes: fatty acid amide hydrolase (FAAH), using inhibitor URB597 (1 mg\/kg); monoacylglycerol lipase (MAGL), using inhibitor URB602 (10 mg\/kg). Administration of quinpirole (1 mg\/kg) caused a temporal biphasic response characterized by a first phase of immobility (0\u201350 min), followed by enhanced locomotion (next 70 min) that was associated with the introduction of stereotyped behaviours (stereotyped jumping and rearing). Pretreatment with both endocannabinoid degradation inhibitors did not affect the hypoactivity actions of quinpirole. However, this pretreatment resulted in a marked decrease in quinpirole-induced locomotion and stereotyped behaviours. Administration of FAAH or MAGL inhibitors did not attenuate the acute effects of cocaine. Furthermore, these inhibitors did not impair the acquisition of cocaine-induced behavioural sensitization or the expression of cocaine-induced conditioned locomotion. Only MAGL inhibition attenuated the expression of an already acquired cocaine-induced behavioural sensitization. These results suggest that pharmacological inhibition of endocannabinoid degradation might exert a negative feedback on D2\/D3 receptor-mediated hyperactivity. This finding might be relevant for therapeutic approaches for either psychomotor disorders (dyskinesia, corea) or disorganized behaviours associated with dopamine-mediated hyperactivity.<\/jats:p>","DOI":"10.1017\/s1461145712000569","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T09:47:27Z","timestamp":1338371247000},"page":"661-676","source":"Crossref","is-referenced-by-count":37,"title":["Hyperactivity induced by the dopamine D2\/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice"],"prefix":"10.1093","volume":"16","author":[{"given":"Mar\u00eda Jes\u00fas","family":"Luque-Rojas","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n IMABIS, Laboratorio de Medicina Regenerativa, Hospital Regional Universitario Carlos Haya, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Galeano","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones \u2018Prof. Dr. Alberto C. Taquini\u2019 (ININCA), Facultad de Medicina, UBA-CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n IMABIS, Laboratorio de Medicina Regenerativa, Hospital Regional Universitario Carlos Haya, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Araos","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n IMABIS, Laboratorio de Medicina Regenerativa, Hospital Regional Universitario Carlos Haya, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis J.","family":"Sant\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiolog\u00eda y Metodolog\u00eda de las Ciencias del Comportamiento, Facultad de Psicolog\u00eda, Universidad de M\u00e1laga, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Rodr\u00edguez","family":"de Fonseca","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n IMABIS, Laboratorio de Medicina Regenerativa, Hospital Regional Universitario Carlos Haya, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Blanco","family":"Calvo","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n IMABIS, Laboratorio de Medicina Regenerativa, Hospital Regional Universitario Carlos Haya, M\u00e1laga, Spain"},{"name":"Departamento de Psicobiolog\u00eda y Metodolog\u00eda de las Ciencias del Comportamiento, Facultad de Psicolog\u00eda, Universidad de M\u00e1laga, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"2019101113404264000_ref1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.brainres.2012.01.030","article-title":"The effects of cannabinoid CB1, CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats","volume":"1444","author":"Adamczyk","year":"2012","journal-title":"Brain Research"},{"key":"2019101113404264000_ref2","doi-asserted-by":"publisher","first-page":"20564","DOI":"10.1073\/pnas.0706873104","article-title":"Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step","volume":"104","author":"Adermark","year":"2007","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"2019101113404264000_ref3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1460-9568.2008.06551.x","article-title":"Endocannabinoid-dependent plasticity at GABAergic and glutamatergic synapses in the striatum is regulated by synaptic activity","volume":"29","author":"Adermark","year":"2009","journal-title":"European Journal of Neuroscience"},{"key":"2019101113404264000_ref4","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.pbb.2005.02.015","article-title":"The role of endocannabinoid transmission in cocaine addiction","volume":"81","author":"Arnold","year":"2005","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"2019101113404264000_ref5","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1523\/JNEUROSCI.20-09-03401.2000","article-title":"Reversal of dopamine D(2) receptor responses by an anandamide transport inhibitor","volume":"20","author":"Beltramo","year":"2000","journal-title":"Journal of Neuroscience"},{"key":"2019101113404264000_ref6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00213-011-2446-6","article-title":"Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors","volume":"220","author":"Blanco","year":"2012","journal-title":"Psychopharmacology"},{"key":"2019101113404264000_ref7","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00213-011-2418-x","article-title":"Cocaine modulates both glutaminase gene expression and glutaminase activity in the brain of cocaine-sensitized mice","volume":"219","author":"Blanco","year":"2012","journal-title":"Psychopharmacology"},{"key":"2019101113404264000_ref8","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/npp.2008.138","article-title":"Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum","volume":"34","author":"Bossong","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"2019101113404264000_ref9","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/S0306-4522(02)00099-4","article-title":"Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions","volume":"112","author":"Chefer","year":"2002","journal-title":"Neuroscience"},{"key":"2019101113404264000_ref10","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.pbb.2005.01.022","article-title":"Endocannabinoid system and alcohol addiction: pharmacological studies","volume":"81","author":"Colombo","year":"2005","journal-title":"Pharmacology, Biochemistry, and Behaviour"},{"key":"2019101113404264000_ref11","doi-asserted-by":"publisher","first-page":"9371","DOI":"10.1073\/pnas.161191698","article-title":"Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase","volume":"98","author":"Cravatt","year":"2001","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"2019101113404264000_ref12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/384083a0","article-title":"Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides","volume":"384","author":"Cravatt","year":"1996","journal-title":"Nature"},{"key":"2019101113404264000_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2011.00369.x","article-title":"Cannabinoid-1 receptor antagonist rimonabant (SR141716) increases striatal dopamine D2 receptor availability","author":"Crunelle","year":"2011","journal-title":"Addiction Biology"},{"key":"2019101113404264000_ref14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1046\/j.1471-4159.1997.68020659.x","article-title":"Dopamine agonist-induced inhibition of neurotransmitter release from the awake squirrel monkey putamen as measured by microdialysis","volume":"68","author":"Davis","year":"1997","journal-title":"Journal of Neurochemistry"},{"key":"2019101113404264000_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2012.01.003","article-title":"Marked inbred mouse strain difference in the expression of quinpirole induced compulsive like behavior based on behavioral pattern analysis","author":"de Haas","year":"2012","journal-title":"European Neuropsychopharmacology"},{"key":"2019101113404264000_ref16","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1038\/nm1001-1151","article-title":"A cannabinoid mechanism in relapse to cocaine seeking","volume":"7","author":"de Vries","year":"2001","journal-title":"Nature Medicine"},{"key":"2019101113404264000_ref17","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/372686a0","article-title":"Formation and inactivation of endogenous cannabinoid anandamide in central neurons","volume":"372","author":"di Marzo","year":"1994","journal-title":"Nature"},{"key":"2019101113404264000_ref18","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/BF02244813","article-title":"Dopaminergic control of locomotion, mouthing, snout contact, and grooming: opposing roles of D1 and D2 receptors","volume":"106","author":"Eilam","year":"1992","journal-title":"Psychopharmacology"},{"key":"2019101113404264000_ref19","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00213-009-1612-6","article-title":"Role of cannabis and endocannabinoids in the genesis of schizophrenia","volume":"206","author":"Fernandez-Espejo","year":"2009","journal-title":"Psychopharmacology"},{"key":"2019101113404264000_ref20","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1046\/j.1460-9568.2003.02896.x","article-title":"Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias","volume":"18","author":"Ferrer","year":"2003","journal-title":"European Journal of Neuroscience"},{"key":"2019101113404264000_ref21","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.ejphar.2007.01.009","article-title":"Cannabinoid CB1 receptor antagonism markedly increases dopamine receptor-mediated stereotypies","volume":"559","author":"Ferrer","year":"2007","journal-title":"European Journal of Pharmacology"},{"key":"2019101113404264000_ref22","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.pbb.2005.01.032","article-title":"Endocannabinoid signaling system and brain reward: emphasis on dopamine","volume":"81","author":"Gardner","year":"2005","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"2019101113404264000_ref23","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1152\/jn.2001.85.1.468","article-title":"CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum","volume":"85","author":"Gerdeman","year":"2001","journal-title":"Journal of Neurophysiology"},{"key":"2019101113404264000_ref24","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1038\/sj.npp.1301648","article-title":"Context-specific reversal of cocaine sensitization by the CB1 cannabinoid receptor antagonist rimonabant","volume":"33","author":"Gerdeman","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"2019101113404264000_ref25","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1038\/sj.npp.1300558","article-title":"Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms","volume":"29","author":"Giuffrida","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"2019101113404264000_ref26","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/7268","article-title":"Dopamine activation of endogenous cannabinoid signaling in dorsal striatum","volume":"2","author":"Giuffrida","year":"1999","journal-title":"Nature Neuroscience"},{"key":"2019101113404264000_ref27","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0009-3084(00)00193-6","article-title":"The endocannabinoid system: a physiological perspective on its role in psychomotor control","volume":"108","author":"Giuffrida","year":"2000","journal-title":"Chemistry and Physics of Lipids"},{"key":"2019101113404264000_ref28","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1460-9568.1997.tb01390.x","article-title":"Modulation of neurotransmission by cannabinoids in the basal ganglia","volume":"9","author":"Glass","year":"1997","journal-title":"European Journal of Neuroscience"},{"key":"2019101113404264000_ref29","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.pbb.2005.02.004","article-title":"Acute delta9-tetrahydrocannabinol exposure facilitates quinpirole-induced hyperlocomotion","volume":"81","author":"Gorriti","year":"2005","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"2019101113404264000_ref30","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0014-2999(98)00851-6","article-title":"Chronic (-)-delta9-tetrahydrocannabinol treatment induces sensitization to the psychomotor effects of amphetamine in rats","volume":"365","author":"Gorriti","year":"1999","journal-title":"European Journal of Pharmacology"},{"key":"2019101113404264000_ref31","doi-asserted-by":"publisher","first-page":"12484","DOI":"10.1523\/JNEUROSCI.3133-07.2007","article-title":"Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin","volume":"27","author":"Hnasko","year":"2007","journal-title":"Journal of Neuroscience"},{"key":"2019101113404264000_ref32","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1038\/nature03658","article-title":"An endocannabinoid mechanism for stress-induced analgesia","volume":"435","author":"Hohmann","year":"2005","journal-title":"Nature"},{"key":"2019101113404264000_ref33","doi-asserted-by":"publisher","first-page":"153","DOI":"10.5607\/en.2011.20.3.153","article-title":"Differential DAergic control of D1 and D2 receptor agonist over locomotor activity and GABA level in the striatum","volume":"20","author":"Jung","year":"2011","journal-title":"Experimental Neurobiology"},{"key":"2019101113404264000_ref34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/nm803","article-title":"Modulation of anxiety through blockade of anandamide hydrolysis","volume":"9","author":"Kathuria","year":"2003","journal-title":"Nature Medicine"},{"key":"2019101113404264000_ref35","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1126\/science.283.5400.401","article-title":"Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice","volume":"283","author":"Ledent","year":"1999","journal-title":"Science"},{"key":"2019101113404264000_ref36","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.euroneuro.2004.04.003","article-title":"Endogenous cannabinoids are not involved in cocaine reinforcement and development of cocaine-induced behavioural sensitization","volume":"15","author":"Lesscher","year":"2005","journal-title":"European Neuropsychopharmacology"},{"key":"2019101113404264000_ref37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00213-008-1432-0","article-title":"Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout mice","volume":"204","author":"Li","year":"2009","journal-title":"Psychopharmacology"},{"key":"2019101113404264000_ref38","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1017\/S1461145709990605","article-title":"A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL\/6JArc mice","volume":"13","author":"Long","year":"2010","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"2019101113404264000_ref39","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1369-1600.2010.00222.x","article-title":"Effects of fatty acid amide hydrolase inhibition on neuronal responses to nicotine, cocaine and morphine in the nucleus accumbens shell and ventral tegmental area: involvement of PPAR-alpha nuclear receptors","volume":"15","author":"Luchicchi","year":"2010","journal-title":"Addiction Biology"},{"key":"2019101113404264000_ref40","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1523\/JNEUROSCI.22-09-03326.2002","article-title":"Cannabinoid addiction: behavioral models and neural correlates","volume":"22","author":"Maldonado","year":"2002","journal-title":"Journal of Neuroscience"},{"key":"2019101113404264000_ref41","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1038\/sj.npp.1301558","article-title":"Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors","volume":"33","author":"Martin","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"2019101113404264000_ref42","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1100\/tsw.2008.136","article-title":"Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-proteincoupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer","volume":"8","author":"Navarro","year":"2008","journal-title":"Scientific World Journal"},{"key":"2019101113404264000_ref43","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0006-8993(88)90749-4","article-title":"The effects of delta 9-tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis study","volume":"451","author":"Ng Cheong Ton","year":"1988","journal-title":"Brain Research"},{"key":"2019101113404264000_ref44","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1111\/j.1471-4159.2008.05782.x","article-title":"D2 receptor-mediated inhibition of dopamine release in the rat striatum in vitro is modulated by CB1 receptors: studies using fast cyclic voltammetry","volume":"108","author":"O'Neill","year":"2009","journal-title":"Journal of Neurochemistry"},{"key":"2019101113404264000_ref45","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.1523\/JNEUROSCI.0563-09.2009","article-title":"A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions","volume":"29","author":"Orio","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"2019101113404264000_ref46","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/nrn1247","article-title":"The molecular logic of endocannabinoid signalling","volume":"4","author":"Piomelli","year":"2003","journal-title":"Nature Reviews. Neuroscience"},{"key":"2019101113404264000_ref47","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.neuropharm.2008.07.047","article-title":"Membrane microdomains and metabolic pathways that define anandamide and 2-arachidonyl glycerol biosynthesis and breakdown","volume":"55","author":"Placzek","year":"2008","journal-title":"Neuropharmacology"},{"key":"2019101113404264000_ref48","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.brainres.2008.12.078","article-title":"Methanandamide attenuates cocaine-induced hyperthermia in rats by a cannabinoid CB(1)-dopamine D(2) receptor mechanism","volume":"1260","author":"Rasmussen","year":"2009","journal-title":"Brain Research"},{"key":"2019101113404264000_ref49","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/0024-3205(90)90132-B","article-title":"Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study","volume":"46","author":"Ritz","year":"1990","journal-title":"Life Sciences"},{"key":"2019101113404264000_ref50","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1006\/nbdi.1998.0217","article-title":"Role of the endogenous cannabinoid system in the regulation of motor activity","volume":"5","author":"Rodriguez de Fonseca","year":"1998","journal-title":"Neurobiology of Disease"},{"key":"2019101113404264000_ref51","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/BF03033228","article-title":"Role of the endogenous cannabinoid system as a modulator of dopamine transmission: implications for Parkinson's disease and schizophrenia","volume":"3","author":"Rodriguez de Fonseca","year":"2001","journal-title":"Neurotoxicity Research"},{"key":"2019101113404264000_ref52","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1097\/00001756-199403000-00006","article-title":"Repeated stimulation of D1 dopamine receptors enhances (\u2212)-11-hydroxy-delta 8-tetrahydrocannabinol-dimethyl-heptyl-induced catalepsy in male rats","volume":"5","author":"Rodriguez de Fonseca","year":"1994","journal-title":"Neuroreport"},{"key":"2019101113404264000_ref53","doi-asserted-by":"publisher","first-page":"468","DOI":"10.2174\/187152708786927859","article-title":"The endocannabinoid system: a new molecular target for the treatment of tobacco addiction","volume":"7","author":"Scherma","year":"2008","journal-title":"CNS and Neurological Disorders Drug Targets"},{"key":"2019101113404264000_ref54","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/bjp.2008.130","article-title":"The endocannabinoid system in brain reward processes","volume":"154","author":"Solinas","year":"2008","journal-title":"British Journal of Pharmacology"},{"key":"2019101113404264000_ref55","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.phrs.2007.09.005","article-title":"Endocannabinoid system involvement in brain reward processes related to drug abuse","volume":"56","author":"Solinas","year":"2007","journal-title":"Pharmacological Research"},{"key":"2019101113404264000_ref56","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1038\/sj.npp.1300707","article-title":"Lack of CB1 cannabinoid receptor impairs cocaine self-administration","volume":"30","author":"Soria","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"2019101113404264000_ref57","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/0091-3057(86)90421-1","article-title":"Grooming in the mouse is stimulated by the dopamine D1 agonist SKF 38393 and by low doses of the D1 antagonist SCH 23390, but is inhibited by dopamine D2 agonists, D2 antagonists and high doses of SCH 23390","volume":"24","author":"Starr","year":"1986","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"2019101113404264000_ref58","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/42015","article-title":"A second endogenous cannabinoid that modulates long-term potentiation","volume":"388","author":"Stella","year":"1997","journal-title":"Nature"},{"key":"2019101113404264000_ref59","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.bbr.2008.12.035","article-title":"Modulation of anxiety by acute blockade and genetic deletion of the CB(1) cannabinoid receptor in mice together with biogenic amine changes in the forebrain","volume":"200","author":"Thiemann","year":"2009","journal-title":"Behavioural Brain Research"},{"key":"2019101113404264000_ref60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/MNH.0b013e3282f29071","article-title":"Role of the endocannabinoid system in metabolic control","volume":"17","author":"Wang","year":"2008","journal-title":"Current Opinion in Nephrology and Hypertension"},{"key":"2019101113404264000_ref61","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/nn.2874","article-title":"Brain cannabinoid CB2 receptors modulate cocaine's actions in mice","volume":"14","author":"Xi","year":"2011","journal-title":"Nature Neuroscience"},{"key":"2019101113404264000_ref62","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1038\/sj.npp.1301552","article-title":"Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats","volume":"33","author":"Xi","year":"2008","journal-title":"Neuropsychopharmacology"}],"container-title":["International Journal of Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/16\/3\/661\/30134540\/16-3-661.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ijnp\/article-pdf\/16\/3\/661\/30134540\/16-3-661.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T16:44:39Z","timestamp":1570812279000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ijnp\/article\/16\/3\/661\/650696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,1]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,4,1]]}},"URL":"https:\/\/doi.org\/10.1017\/s1461145712000569","relation":{},"ISSN":["1469-5111","1461-1457"],"issn-type":[{"value":"1469-5111","type":"electronic"},{"value":"1461-1457","type":"print"}],"subject":[],"published-other":{"date-parts":[[2013,4]]},"published":{"date-parts":[[2013,4,1]]}}}