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We tested the hypotheses that serotonin transporter (5-HTT) binding is elevated in PD subjects vs. healthy controls in regions where in vivo evidence exists for both elevated 5-HTT and 5-HT1A receptor levels in PD and investigated whether the extent of this difference depends upon gender. Volunteers were out-patients with current PD (n=24) and healthy controls (n=24). The non-displaceable component of 5-HTT binding-potential (BPND) was measured using positron emission tomography and the 5-HTT selective radioligand, [11C]DASB. PD severity was assessed using the PD Severity Scale. The 5-HTT-BPND was increased in males with PD relative to male controls in the anterior cingulate cortex (F=8.96, pFDR=0.01) and midbrain (F=5.09, pFDR=0.03). In contrast, BPND did not differ between females with PD and female controls in any region examined. The finding that 5-HTT-binding is elevated in males but not in females with PD converges with other evidence suggesting that dysfunction within the central serotonergic system exists in PD, and also indicates that such abnormalities are influenced by gender. These findings conceivably may reflect a sexual dimorphism that underlies the greater efficacy of serotonin reuptake inhibitor treatment in females vs. males with PD.<\/jats:p>","DOI":"10.1017\/s1461145712000776","type":"journal-article","created":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T12:42:58Z","timestamp":1346935378000},"page":"733-743","source":"Crossref","is-referenced-by-count":19,"title":["Gender-specific abnormalities in the serotonin transporter system in panic disorder"],"prefix":"10.1093","volume":"16","author":[{"given":"Dara M.","family":"Cannon","sequence":"first","affiliation":[{"name":"Clinical Neuroimaging Laboratory, Departments of Anatomy and Psychiatry, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland"},{"name":"National Institutes of Mental Health, Mood and Anxiety Disorders Program, Molecular Imaging Branch, NIMH, NIH, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M.","family":"Klaver","sequence":"additional","affiliation":[{"name":"National Institutes of Mental Health, Mood and Anxiety Disorders Program, Molecular Imaging Branch, NIMH, NIH, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Summer A.","family":"Klug","sequence":"additional","affiliation":[{"name":"National Institutes of Mental Health, Mood and Anxiety Disorders Program, Molecular Imaging Branch, NIMH, NIH, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Carlson","sequence":"additional","affiliation":[{"name":"The Brain Institute, University of Utah, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Luckenbaugh","sequence":"additional","affiliation":[{"name":"National Institutes of Mental Health, Mood and Anxiety Disorders Program, Molecular Imaging Branch, NIMH, NIH, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Ichise","sequence":"additional","affiliation":[{"name":"Department of Radiology, Columbia University, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne C.","family":"Drevets","sequence":"additional","affiliation":[{"name":"National Institutes of Mental Health, Mood and Anxiety Disorders Program, Molecular Imaging Branch, NIMH, NIH, Bethesda, MD, USA"},{"name":"Laureate Institute for Brain Research, Tulsa, OK, USA"},{"name":"Department of Psychiatry, The University of Oklahoma College of Medicine, Tulsa, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,5,1]]},"reference":[{"key":"2019101113403128100_ref1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)","author":"APA","year":"1994"},{"key":"2019101113403128100_ref2","volume-title":"American Psychiatric Association. 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