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At baseline, patients underwent functional magnetic resonance imaging while performing a verbal n-back task. Spatial independent component analysis identified task-modulated brain networks. A linear support vector machine was trained with these components to discriminate six patients who showed improvement in negative symptoms from eight non-improvers. Classification accuracy and significance was estimated by leave-one-out cross-validation and permutation tests, respectively. Two frontoparietal and one default mode network components predicted negative symptom improvement with a classification accuracy of 79% (p = 0.003). Discriminating features were found in the frontoparietal networks but not the default mode network. These preliminary data suggest that functional patterns at baseline can predict negative symptom treatment\u2013response in schizophrenia. This information may be used to stratify patients into subgroups thereby facilitating personalized treatment.<\/jats:p>","DOI":"10.1017\/s1461145712001253","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T13:51:46Z","timestamp":1353419506000},"page":"1195-1204","source":"Crossref","is-referenced-by-count":34,"title":["Neural markers of negative symptom outcomes in distributed working memory brain activity of antipsychotic-naive schizophrenia patients"],"prefix":"10.1093","volume":"16","author":[{"given":"Ayna B.","family":"Nejad","sequence":"first","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark"},{"name":"Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Psychiatric Center Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer H.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark"},{"name":"DTU Informatics, Technical University of Denmark, Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn H.","family":"Ebdrup","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Psychiatric Center Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartwig R.","family":"Siebner","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark"},{"name":"Department of Neurology, Psychiatry and Sensory Sciences, Faculty of Health Sciences, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Psychiatric Center Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil","family":"Aggern\u00e6s","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Psychiatric Center Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte Y.","family":"Glenth\u00f8j","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Copenhagen University Hospital, Psychiatric Center Glostrup, Denmark"},{"name":"Department of Neurology, Psychiatry and Sensory Sciences, Faculty of Health Sciences, University of Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F. 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