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Acute risperidone administration at doses 10\u2013100 \u00b5g\/kg potently and dose-dependently inhibited reinstatement of conditioned cue-induced heroin seeking; the minimum dose of inhibition was 30 \u00b5g\/kg. In contrast, risperidone at the same doses did not attenuate reinstatement induced by two priming doses of heroin (100 or 250 \u00b5g\/kg s.c.). Risperidone at these doses failed to alter heroin self-administration and locomotion activity. These data demonstrate that acute treatment with low-dose risperidone inhibits conditioned cue-induced heroin seeking and risperidone may be an adjunctive therapy for the treatment of heroin addiction.<\/jats:p>","DOI":"10.1017\/s1461145712001563","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T14:41:08Z","timestamp":1358520068000},"page":"1569-1575","source":"Crossref","is-referenced-by-count":25,"title":["Low dose risperidone attenuates cue-induced but not heroin-induced reinstatement of heroin seeking in an animal model of relapse"],"prefix":"10.1093","volume":"16","author":[{"given":"Miaojun","family":"Lai","sequence":"first","affiliation":[{"name":"Laboratory of Behavioral Neuroscience, Ningbo Addiction Research and Treatment Center, School of Medicine, Ningbo University, Ningbo, P. R. 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