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In this study involving 64 individuals, we examined the associations between prefrontal cortical GABA concentration and 12 single nucleotide polymorphisms (SNPs) spanning the TPH2 gene, including rs4570625 (\u2212703 G\/T SNP), a potentially functional TPH2 polymorphism that has been associated with decreased TPH2 mRNA expression and panic disorder. Our results revealed a significant association between increased GABA concentration in the PFC and the T-allele frequencies of two TPH2 SNPs, namely rs4570625 (\u2212703 G\/T) and rs2129575 (p\u2a7d0.0004) and the C-allele frequency of one TPH2 SNP, namely rs1386491 (p = 0.0003) in female subjects. We concluded that rs4570625 (\u2212703 G\/T), rs2129575 and rs1386491 play a significant role in GABAergic neurotransmission and may contribute to the sex-specific dysfunction of the GABAergic system in the PFC.<\/jats:p>","DOI":"10.1017\/s1461145713000254","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T17:25:26Z","timestamp":1365009926000},"page":"1707-1717","source":"Crossref","is-referenced-by-count":14,"title":["Associations between prefrontal \u03b3-aminobutyric acid concentration and the tryptophan hydroxylase isoform 2 gene, a panic disorder risk allele in women"],"prefix":"10.1093","volume":"16","author":[{"given":"Nora","family":"Preuss","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basira","family":"Salehi","sequence":"additional","affiliation":[{"name":"Psychiatric University Hospital, University of Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Willem","family":"van der Veen","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health, Magnetic Resonance Spectroscopy Core, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale School of Medicine, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne C.","family":"Drevets","sequence":"additional","affiliation":[{"name":"Laureate Institute for Brain Research, and University of Oklahoma College of Medicine, Tulsa, OK, USA"},{"name":"Janssen Research and Development, LLC of Johnson and Johnson, Inc., Titusville, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Hodgkinson","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics, National Institute on Alcohol Abuse and 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