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Twelve unmedicated patients with major depressive disorder (MDD) and 24 Con completed PET scans with [11C]raclopride, once without receiving monetary rewards (baseline) and once while winning money. In Con, the A1 allele was associated with reduced baseline binding potential (BPND) in the middle caudate and ventral striatum. However, in MDD patients the A1 allele was associated with increased baseline BPND in these regions. There were no significant associations between rs1800497 and change in BPND during reward-associated dopamine release. Conceivably, the A1 allele predisposes to depression and addiction via its effect on the post-synaptic D2 receptor.<\/jats:p>","DOI":"10.1017\/s146114571300045x","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T08:10:02Z","timestamp":1369037402000},"page":"2095-2101","source":"Crossref","is-referenced-by-count":67,"title":["DRD2\/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2\/3 receptor binding in healthy controls and patients with major depressive disorder"],"prefix":"10.1093","volume":"16","author":[{"given":"Jonathan","family":"Savitz","sequence":"first","affiliation":[{"name":"Laureate Institute for Brain Research, Tulsa, OK, USA"},{"name":"Faculty of Community Medicine, University of Tulsa, Tulsa, OK, USA"},{"name":"Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH\/NIMH, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin 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