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We first discovered that the distribution of tryptophan hydroxylase immunoreactivity in the caudal raphe system was modulated on postnatal day (PD) 28 of the VPA-exposed offspring. Then, we found a significantly higher serotonin transporter availability in the amygdala of the VPA-exposed offspring on PD 56 by using single photon emission computed tomography and computed tomography co-registration following injection of 123I-labeled 2-((2-(dimethylamino)methyl)phenyl)thio)-5-iodophenylamine(123I[ADAM]). Furthermore, treatment with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a 5-HT1A receptor agonist, increased social interaction and improved fear memory extinction in the VPA-exposed offspring. 8-OH-DPAT treatment also reversed the characteristics of miniature excitatory post-synaptic currents as well as paired pulse facilitation observed in lateral amygdala slices. These results provided further evidence to support the role of the amygdala in characteristic behavioral changes in the rat ASD model. The serotonergic projections that modulate the amygdala function might play a certain role in the development and treatment of behavioral symptoms exhibited in individuals with ASD.<\/jats:p>","DOI":"10.1017\/s1461145713000473","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T15:11:24Z","timestamp":1372864284000},"page":"2027-2039","source":"Crossref","is-referenced-by-count":52,"title":["5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model"],"prefix":"10.1093","volume":"16","author":[{"given":"Chao-Chuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anatomy, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"Department and Institute of Physiology, School of Medicine, National Yang-Ming 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