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Data obtained in recent years revealed that the NMDA receptor antagonist phencyclidine (PCP) and the serotonergic hallucinogen 1-(2,5-dimethoxy-4-iodophenyl-2-aminopropane; DOI) produce a series of common actions in rodent prefrontal cortex (PFC) that may underlie psychotomimetic effects. Hence, both agents markedly disrupt PFC function by altering pyramidal neuron discharge (with an overall increase) and reducing the power of low frequency cortical oscillations (LFCO; &lt; 4 Hz). In parallel, PCP increased c-fos expression in excitatory neurons of various cortical areas, the thalamus and other subcortical structures, such as the amygdala. Electrophysiological studies revealed that PCP altered similarly the function of the centromedial and mediodorsal nuclei of the thalamus, reciprocally connected with PFC, suggesting that its psychotomimetic properties are mediated by an alteration of thalamocortical activity (the effect of DOI was not examined in the thalamus). Interestingly, the observed effects were prevented or reversed by the antipsychotic drugs clozapine and haloperidol, supporting that the disruption of PFC activity is intimately related to the psychotomimetic activity of these agents. Overall, the present experimental model can be successfully used to elucidate the neurobiological basis of schizophrenia symptoms and to examine the potential antipsychotic activity of new drugs in development.<\/jats:p>","DOI":"10.1017\/s1461145713000643","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T08:02:40Z","timestamp":1372665760000},"page":"2145-2163","source":"Crossref","is-referenced-by-count":29,"title":["Disruption of thalamocortical activity in schizophrenia models: relevance to antipsychotic drug action"],"prefix":"10.1093","volume":"16","author":[{"given":"Pau","family":"Celada","sequence":"first","affiliation":[{"name":"Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona, (IIBB-CSIC), Barcelona, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Llad\u00f3-Pelfort","sequence":"additional","affiliation":[{"name":"Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona, (IIBB-CSIC), Barcelona, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona, (IIBB-CSIC), Barcelona, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Kargieman","sequence":"additional","affiliation":[{"name":"Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona, (IIBB-CSIC), Barcelona, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Troyano-Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Neurochemistry and Neuropharmacology, Institut d'Investigacions Biom\u00e8diques de Barcelona, (IIBB-CSIC), Barcelona, Spain."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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