{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:47:43Z","timestamp":1793173663137,"version":"4.5.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"16","license":[{"start":{"date-parts":[[2004,2,13]],"date-time":"2004-02-13T00:00:00Z","timestamp":1076630400000},"content-version":"unspecified","delay-in-days":238,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Rev. Mol. Med."],"published-print":{"date-parts":[[2003,6,20]]},"abstract":"<jats:p>The pleiotropic nature of the clinical phenotypes of patients with ataxia-telangiectasia (A-T) \u2013 which encompass cerebellar degeneration (leading to ataxia), gonadal atrophy, and cancer predisposition \u2013 suggests multiple functions of the gene responsible for the disease. The ataxia-telangiectasia mutated gene product (ATM), whose loss of function is responsible for ataxia-telangiectasia, is a protein kinase that interacts with several substrates and is implicated in mitogenic signal transduction, chromosome condensation, meiotic recombination, cell-cycle control and telomere maintenance. This review focuses on the critical roles that ATM appears to play in cell-cycle checkpoints, DNA repair, telomere metabolism and oxidative stress, indicating how defects in these processes might lead to ataxia-telangiectasia.<\/jats:p>","DOI":"10.1017\/s1462399403006318","type":"journal-article","created":{"date-parts":[[2003,10,29]],"date-time":"2003-10-29T15:21:13Z","timestamp":1067440873000},"page":"1-21","source":"Crossref","is-referenced-by-count":37,"title":["A multifaceted role for ATM in genome maintenance"],"prefix":"10.1017","volume":"5","author":[{"given":"Tej K.","family":"Pandita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2004,2,13]]},"container-title":["Expert Reviews in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1462399403006318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T19:39:10Z","timestamp":1553888350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1462399403006318\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,20]]},"references-count":0,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2003,6,20]]}},"alternative-id":["S1462399403006318"],"URL":"https:\/\/doi.org\/10.1017\/s1462399403006318","relation":{},"ISSN":["1462-3994"],"issn-type":[{"value":"1462-3994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,20]]}}}