{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:50:28Z","timestamp":1789609828444,"version":"build-2803163510"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T00:00:00Z","timestamp":1106611200000},"content-version":"unspecified","delay-in-days":1,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Rev. Mol. Med."],"published-print":{"date-parts":[[2005,1,24]]},"abstract":"<jats:p>Since its identification in the early 1990s, peroxisome-proliferator-activated receptor \u03b3 (PPAR\u03b3), a nuclear hormone receptor, has attracted tremendous scientific and clinical interest. The role of PPAR\u03b3 in macronutrient metabolism has received particular attention, for three main reasons: first, it is the target of the thiazolidinediones (TZDs), a novel class of insulin sensitisers widely used to treat type 2 diabetes; second, it plays a central role in adipogenesis; and third, it appears to be primarily involved in regulating lipid metabolism with predominantly secondary effects on carbohydrate metabolism, a notion in keeping with the currently in vogue \u2018lipocentric\u2019 view of diabetes. This review summarises in vitro studies suggesting that PPAR\u03b3 is a master regulator of adipogenesis, and then considers in vivo findings from use of PPAR\u03b3 agonists, knockout studies in mice and analysis of human PPAR\u03b3 mutations\/polymorphisms. <\/jats:p>","DOI":"10.1017\/s1462399405008793","type":"journal-article","created":{"date-parts":[[2005,1,30]],"date-time":"2005-01-30T15:49:22Z","timestamp":1107100162000},"page":"1-16","source":"Crossref","is-referenced-by-count":59,"title":["PPAR\u03b3 as a metabolic regulator: insights from genomics and pharmacology"],"prefix":"10.1017","volume":"7","author":[{"given":"David B.","family":"Savage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2005,1,25]]},"container-title":["Expert Reviews in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1462399405008793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T20:47:14Z","timestamp":1750452434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1462399405008793\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,24]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,5,6]]}},"alternative-id":["S1462399405008793"],"URL":"https:\/\/doi.org\/10.1017\/s1462399405008793","relation":{},"ISSN":["1462-3994"],"issn-type":[{"value":"1462-3994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,24]]}}}