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Increased androgen synthesis, disrupted folliculogenesis and insulin resistance lie at the pathophysiological core of PCOS. An intriguing concept involves the perpetuation of a vicious circle with endocrine\/reproductive and metabolic components. An unfavourable metabolic environment may unmask genetic traits of ovarian dysfunction, and the unfolding endocrine derangement could further aggravate the metabolic disarray. This article reviews the molecular mechanisms known to underlie the ovarian and metabolic abnormalities characterising PCOS. The putative interdependence between reproductive and metabolic aspects of PCOS, and therapeutic implications for the management of PCOS, are also discussed.<\/jats:p>","DOI":"10.1017\/s1462399408000598","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T12:53:45Z","timestamp":1201697625000},"source":"Crossref","is-referenced-by-count":221,"title":["Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications"],"prefix":"10.1017","volume":"10","author":[{"given":"Evanthia","family":"Diamanti-Kandarakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2008,1,30]]},"reference":[{"key":"S1462399408000598_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00421-0"},{"key":"S1462399408000598_ref125","first-page":"367","volume-title":"In Pharmaceutical Intervention in Metabolic and Cardiovascular Risk Factors in Polycystic 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