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Aquaporins also facilitate water movement into and out of the brain in various pathologies such as stroke, tumour, infection and hydrocephalus. A major, unexpected cellular role of aquaporins was revealed by analysis of knockout mice: aquaporins facilitate cell migration, as occurs in angiogenesis, tumour metastasis, wound healing, and glial scar formation. Another unexpected role of aquaporins is in neural function \u2013 in sensory signalling and seizure activity. The water-transporting function of aquaporins is likely responsible for these roles. A subset of aquaporins that transport both water and glycerol, the \u2018aquaglyceroporins\u2019, regulate glycerol content in epidermal, fat and other tissues. Mice lacking various aquaglyceroporins have several interesting phenotypes, including dry skin, resistance to skin carcinogenesis, impaired cell proliferation, and altered fat metabolism. The various roles of aquaporins might be exploited clinically by development of drugs to alter aquaporin expression or function, which could serve as diuretics, and in the treatment of brain swelling, glaucoma, epilepsy, obesity and cancer.<\/jats:p>","DOI":"10.1017\/s1462399408000690","type":"journal-article","created":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T07:37:28Z","timestamp":1210923448000},"source":"Crossref","is-referenced-by-count":121,"title":["Mammalian aquaporins: diverse physiological roles and potential clinical significance"],"prefix":"10.1017","volume":"10","author":[{"given":"A. 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