{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:54:37Z","timestamp":1791453277077,"version":"4.3.3"},"reference-count":137,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T00:00:00Z","timestamp":1250726400000},"content-version":"unspecified","delay-in-days":19,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Expert Rev. Mol. Med."],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>Infiltration of T cells is a key step in the pathogenesis of the inflammatory skin diseases atopic dermatitis, allergic contact dermatitis and psoriasis. Understanding the mechanisms of T cell recruitment to the skin is therefore of fundamental importance for the discovery and application of novel therapies for these conditions. Studies of both clinical samples and experimental models of skin inflammation have implicated specific adhesion molecules and chemokines in lymphocyte recruitment. In particular, recent studies using advanced in vivo imaging techniques have greatly increased our understanding of the kinetics and molecular basis of this process. In this review, we summarise the current understanding of the cellular immunology of antigen-driven dermal inflammation and the roles of adhesion molecules and chemokines. We focus on results obtained using intravital microscopy to examine the dermal microvasculature and interstitium to determine the mechanisms of T cell recruitment and migration in experimental models of T-cell-mediated skin inflammation.<\/jats:p>","DOI":"10.1017\/s146239940900115x","type":"journal-article","created":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T11:07:52Z","timestamp":1250766472000},"source":"Crossref","is-referenced-by-count":33,"title":["Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging"],"prefix":"10.1017","volume":"11","author":[{"given":"James A.","family":"Deane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Hickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,8,20]]},"reference":[{"key":"S146239940900115X_ref100","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032177"},{"key":"S146239940900115X_ref46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.151860b"},{"key":"S146239940900115X_ref118","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.07.015"},{"key":"S146239940900115X_ref133","first-page":"131","article-title":"The role of CD4+ and CD8+ T cells in contact hypersensitivity and allergic contact dermatitis","volume":"14","author":"Saint-Mezard","year":"2004","journal-title":"European Journal of Dermatology"},{"key":"S146239940900115X_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.10.011"},{"key":"S146239940900115X_ref18","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20032016"},{"key":"S146239940900115X_ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000078765"},{"key":"S146239940900115X_ref34","doi-asserted-by":"publisher","DOI":"10.1038\/19546"},{"key":"S146239940900115X_ref137","unstructured":"http:\/\/www.aad.org\/"},{"key":"S146239940900115X_ref77","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.5.2139"},{"key":"S146239940900115X_ref91","doi-asserted-by":"publisher","DOI":"10.1038\/nature06887"},{"key":"S146239940900115X_ref66","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.11.1669"},{"key":"S146239940900115X_ref101","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63986-7"},{"key":"S146239940900115X_ref12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021562"},{"key":"S146239940900115X_ref121","doi-asserted-by":"publisher","DOI":"10.1080\/09546630902984596"},{"key":"S146239940900115X_ref68","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80217-4"},{"key":"S146239940900115X_ref19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.510"},{"key":"S146239940900115X_ref108","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142883"},{"key":"S146239940900115X_ref83","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.12.2091"},{"key":"S146239940900115X_ref80","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.497"},{"key":"S146239940900115X_ref11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6225"},{"key":"S146239940900115X_ref113","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070051"},{"key":"S146239940900115X_ref120","doi-asserted-by":"publisher","DOI":"10.1177\/120347540500900606"},{"key":"S146239940900115X_ref3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117408"},{"key":"S146239940900115X_ref105","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.4.601"},{"key":"S146239940900115X_ref95","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.3.451"},{"key":"S146239940900115X_ref96","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070225"},{"key":"S146239940900115X_ref1","first-page":"284","article-title":"Allergic contact dermatitis","volume":"14","author":"Saint-Mezard","year":"2004","journal-title":"European Journal of Dermatology"},{"key":"S146239940900115X_ref73","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.03.011"},{"key":"S146239940900115X_ref63","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90041-8"},{"key":"S146239940900115X_ref99","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14470"},{"key":"S146239940900115X_ref13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020649"},{"key":"S146239940900115X_ref97","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.9.1105"},{"key":"S146239940900115X_ref110","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.4049\/jimmunol.162.2.1137","article-title":"Varying roles of E-selectin and P-selectin in different microvascular beds in response to antigen","volume":"162","author":"Hickey","year":"1999","journal-title":"Journal of Immunology"},{"key":"S146239940900115X_ref2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.106"},{"key":"S146239940900115X_ref54","first-page":"S77","article-title":"The integrin VLA-4 mediates leukocyte recruitment to skin inflammatory sites in vivo","volume":"11","author":"Elices","year":"1993","journal-title":"Clinical and Experimental Rheumatology"},{"key":"S146239940900115X_ref116","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060710"},{"key":"S146239940900115X_ref30","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.1001"},{"key":"S146239940900115X_ref104","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.6.3358"},{"key":"S146239940900115X_ref37","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.6.1077"},{"key":"S146239940900115X_ref31","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1864"},{"key":"S146239940900115X_ref24","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.6.995"},{"key":"S146239940900115X_ref107","first-page":"H1199","article-title":"Spontaneous leukocyte rolling in venules in untraumatized skin of conscious and anesthetized animals","volume":"267","author":"Janssen","year":"1994","journal-title":"American Journal of Physiology"},{"key":"S146239940900115X_ref128","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1182\/blood.V91.8.2886.2886_2886_2895","article-title":"A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4","volume":"91","author":"Nakano","year":"1998","journal-title":"Blood"},{"key":"S146239940900115X_ref44","doi-asserted-by":"publisher","DOI":"10.1038\/ni.f.213"},{"key":"S146239940900115X_ref78","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.1119"},{"key":"S146239940900115X_ref130","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090620"},{"key":"S146239940900115X_ref111","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.9.4728"},{"key":"S146239940900115X_ref79","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3581"},{"key":"S146239940900115X_ref40","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.4049\/jimmunol.163.6.3441","article-title":"Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: a critical role for the \u03b14-integrin","volume":"163","author":"Hickey","year":"1999","journal-title":"Journal of Immunology"},{"key":"S146239940900115X_ref53","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.4049\/jimmunol.162.3.1648","article-title":"Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice: evidence for a dominant role of TNF-alpha","volume":"162","author":"McHale","year":"1999","journal-title":"Journal of Immunology"},{"key":"S146239940900115X_ref67","doi-asserted-by":"publisher","DOI":"10.1038\/40166"},{"key":"S146239940900115X_ref51","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.151456"},{"key":"S146239940900115X_ref41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.520"},{"key":"S146239940900115X_ref49","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-134429"},{"key":"S146239940900115X_ref72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2112"},{"key":"S146239940900115X_ref76","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.5.601"},{"key":"S146239940900115X_ref71","doi-asserted-by":"publisher","DOI":"10.1038\/385081a0"},{"key":"S146239940900115X_ref8","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.4049\/jimmunol.144.11.4121","article-title":"Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion","volume":"144","author":"Gocinski","year":"1990","journal-title":"Journal of Immunology"},{"key":"S146239940900115X_ref87","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031562"},{"key":"S146239940900115X_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/44385"},{"key":"S146239940900115X_ref21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00038.x"},{"key":"S146239940900115X_ref89","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.9.5444"},{"key":"S146239940900115X_ref26","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.6783"},{"key":"S146239940900115X_ref52","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1356"},{"key":"S146239940900115X_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.06.003"},{"key":"S146239940900115X_ref135","volume-title":"Immunology, Immunopathology and Therapeutic Perspectives","author":"Boehncke","year":"2005"},{"key":"S146239940900115X_ref60","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.6.2341"},{"key":"S146239940900115X_ref125","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701011"},{"key":"S146239940900115X_ref4","doi-asserted-by":"publisher","DOI":"10.1038\/ng.358"},{"key":"S146239940900115X_ref33","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070081"},{"key":"S146239940900115X_ref35","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060925"},{"key":"S146239940900115X_ref93","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80165-X"},{"key":"S146239940900115X_ref115","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050011"},{"key":"S146239940900115X_ref85","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7911"},{"key":"S146239940900115X_ref122","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.4431"},{"key":"S146239940900115X_ref43","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"S146239940900115X_ref17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.3.1588"},{"key":"S146239940900115X_ref65","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1182\/blood.V88.8.2973.bloodjournal8882973","article-title":"Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin","volume":"88","author":"Staite","year":"1996","journal-title":"Blood"},{"key":"S146239940900115X_ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.12.020"},{"key":"S146239940900115X_ref64","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.6.2277"},{"key":"S146239940900115X_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"S146239940900115X_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380220076026"},{"key":"S146239940900115X_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0531-7"},{"key":"S146239940900115X_ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912093412407"},{"key":"S146239940900115X_ref16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.4049\/jimmunol.146.2.469","article-title":"Delayed-type hypersensitivity initiation by early-acting cells that are antigen mismatched or MHC incompatible with late-acting, delayed-type hypersensitivity effector T cells","volume":"146","author":"Ptak","year":"1991","journal-title":"Journal of Immunology"},{"key":"S146239940900115X_ref20","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080052"},{"key":"S146239940900115X_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830251103"},{"key":"S146239940900115X_ref23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00236.x"},{"key":"S146239940900115X_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00391-6"},{"key":"S146239940900115X_ref27","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3485::AID-IMMU3485>3.0.CO;2-B"},{"key":"S146239940900115X_ref29","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636207"},{"key":"S146239940900115X_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.04.015"},{"key":"S146239940900115X_ref36","doi-asserted-by":"publisher","DOI":"10.1038\/nri2532"},{"key":"S146239940900115X_ref59","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.6.2259"},{"key":"S146239940900115X_ref38","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.4049\/jimmunol.162.5.2709","article-title":"Overlapping roles for L-selectin and P-selectin in antigen-induced immune responses in the microvasculature","volume":"162","author":"Kanwar","year":"1999","journal-title":"Journal of Immunology"},{"key":"S146239940900115X_ref39","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.5.1995"},{"key":"S146239940900115X_ref42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.37.21966"},{"key":"S146239940900115X_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90337-9"},{"key":"S146239940900115X_ref48","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060565"},{"key":"S146239940900115X_ref50","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.6.1854"},{"key":"S146239940900115X_ref88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192162899"},{"key":"S146239940900115X_ref55","first-page":"1286","article-title":"Dual inhibition of VLA-4 and LFA-1 maximally inhibits cutaneous delayed-type hypersensitivity-induced inflammation","volume":"143","author":"Issekutz","year":"1993","journal-title":"American Journal of Pathology"},{"key":"S146239940900115X_ref56","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4049\/jimmunol.150.2.655","article-title":"Reduced contact sensitivity reactions in mice treated with monoclonal antibodies to leukocyte function-associated molecule-1 and intercellular adhesion molecule-1","volume":"150","author":"Scheynius","year":"1993","journal-title":"Journal of Immunology"},{"key":"S146239940900115X_ref57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.18.8529"},{"key":"S146239940900115X_ref58","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.95"},{"key":"S146239940900115X_ref61","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1182\/blood.V93.2.580","article-title":"Selective requirements for leukocyte adhesion molecules in models of acute and chronic cutaneous inflammation: participation of E- and P- but not L-selectin","volume":"93","author":"Catalina","year":"1999","journal-title":"Blood"},{"key":"S146239940900115X_ref62","doi-asserted-by":"crossref","first-page":"6860","DOI":"10.4049\/jimmunol.163.12.6860","article-title":"Endothelial cell E- and P-selectin up-regulation in murine contact sensitivity is prolonged by distinct mechanisms occurring in sequence","volume":"163","author":"Harari","year":"1999","journal-title":"Journal of Immunology"},{"key":"S146239940900115X_ref69","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.3.560"},{"key":"S146239940900115X_ref70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.24.9238"},{"key":"S146239940900115X_ref74","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700805"},{"key":"S146239940900115X_ref75","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.4.2499"},{"key":"S146239940900115X_ref81","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.00348.x"},{"key":"S146239940900115X_ref82","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1182\/blood.V90.6.2217","article-title":"CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity","volume":"90","author":"Schmits","year":"1997","journal-title":"Blood"},{"key":"S146239940900115X_ref84","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1182\/blood.V95.5.1804.005k11_1804_1809","article-title":"Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue","volume":"95","author":"Werr","year":"2000","journal-title":"Blood"},{"key":"S146239940900115X_ref86","doi-asserted-by":"publisher","DOI":"10.1038\/372190a0"},{"key":"S146239940900115X_ref90","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6583"},{"key":"S146239940900115X_ref92","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.12.3853"},{"key":"S146239940900115X_ref94","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80059-8"},{"key":"S146239940900115X_ref98","doi-asserted-by":"publisher","DOI":"10.1038\/23495"},{"key":"S146239940900115X_ref102","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.10.1541"},{"key":"S146239940900115X_ref103","doi-asserted-by":"publisher","DOI":"10.1038\/nm0202-157"},{"key":"S146239940900115X_ref106","first-page":"H157","article-title":"Leukocyte rolling: a prominent feature of venules in intact skin of anaesthetized hairless mice","volume":"262","author":"Mayrovitz","year":"1992","journal-title":"American Journal of Physiology"},{"key":"S146239940900115X_ref109","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3510-08.2008"},{"key":"S146239940900115X_ref112","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth1018"},{"key":"S146239940900115X_ref114","doi-asserted-by":"publisher","DOI":"10.1038\/nature02238"},{"key":"S146239940900115X_ref117","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.10.015"},{"key":"S146239940900115X_ref119","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000222"},{"key":"S146239940900115X_ref123","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12325538"},{"key":"S146239940900115X_ref124","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.4049\/jimmunol.159.5.2484","article-title":"Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile","volume":"159","author":"Kitagaki","year":"1997","journal-title":"Journal of Immunology"},{"key":"S146239940900115X_ref126","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060747"},{"key":"S146239940900115X_ref127","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.8.4325"},{"key":"S146239940900115X_ref129","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"S146239940900115X_ref132","first-page":"284","article-title":"Allergic contact dermatitis","volume":"14","author":"Saint-Mezard","year":"2004","journal-title":"European Journal of Dermatology"},{"key":"S146239940900115X_ref134","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2005.05.019"},{"key":"S146239940900115X_ref136","unstructured":"http:\/\/www.nlm.nih.gov\/medlineplus\/skinconditions.html The American Academy of Dermatology is the peak body representing dermatologists in the USA and provides an extensive resource for public education on diseases of the skin:"},{"key":"S146239940900115X_ref131","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00584.x"}],"container-title":["Expert Reviews in Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S146239940900115X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T11:46:41Z","timestamp":1685101601000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S146239940900115X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":137,"alternative-id":["S146239940900115X"],"URL":"https:\/\/doi.org\/10.1017\/s146239940900115x","relation":{},"ISSN":["1462-3994"],"issn-type":[{"value":"1462-3994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8]]},"article-number":"e25"}}