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Treatment of trypanosome infections is dependent on a small number of drugs that have limited efficacy and can cause severe side effects. Here, we review the properties of these drugs and describe new findings on their modes of action and the mechanisms by which resistance can arise. We further outline how a greater understanding of parasite biology is being exploited in the search for novel chemotherapeutic agents. This effort is being facilitated by new research networks that involve academic and biotechnology\/pharmaceutical organisations, supported by public\u2013private partnerships, and are bringing a new dynamism and purpose to the search for trypanocidal agents.<\/jats:p>","DOI":"10.1017\/s1462399409001252","type":"journal-article","created":{"date-parts":[[2009,10,29]],"date-time":"2009-10-29T09:47:11Z","timestamp":1256809631000},"source":"Crossref","is-referenced-by-count":195,"title":["Trypanocidal drugs: mechanisms, resistance and new targets"],"prefix":"10.1017","volume":"11","author":[{"given":"Shane R.","family":"Wilkinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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