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Body iron load can also be increased by repeated blood transfusions (secondary iron loading), usually as part of the treatment for various haematological disorders. In these syndromes, an element of enhanced iron absorption is also often involved. The central regulator of body iron trafficking is the liver-derived peptide hepcidin. Hepcidin limits iron entry into the plasma from macrophages, intestinal enterocytes and other cells by binding to the sole iron-export protein ferroportin, and facilitating its removal from the plasma membrane. Mutations in hepcidin or its upstream regulators (HFE, TFR2, HFE2 and BMP6) lead to reduced or absent hepcidin expression and a concomitant increase in iron absorption. Mutations in ferroportin that prevent hepcidin binding produce a similar result. Increased ineffective erythropoiesis, which often characterises erythrocyte disorders, also leads to reduced hepcidin expression and increased absorption. Recent advances in our understanding of hepcidin and body iron homeostasis provide the potential for a range of new diagnostic and therapeutic tools for haemochromatosis and related conditions.<\/jats:p>","DOI":"10.1017\/s1462399410001687","type":"journal-article","created":{"date-parts":[[2010,11,8]],"date-time":"2010-11-08T09:47:35Z","timestamp":1289209655000},"source":"Crossref","is-referenced-by-count":42,"title":["Molecular basis of iron-loading disorders"],"prefix":"10.1017","volume":"12","author":[{"given":"Deepak","family":"Darshan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Frazer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,11,8]]},"reference":[{"key":"S1462399410001687_ref132","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2009.02.004"},{"key":"S1462399410001687_ref121","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-245209"},{"key":"S1462399410001687_ref140","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-261875"},{"key":"S1462399410001687_ref120","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-126854"},{"key":"S1462399410001687_ref111","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.006270"},{"key":"S1462399410001687_ref110","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.04.032"},{"key":"S1462399410001687_ref105","doi-asserted-by":"crossref","unstructured":"105 Nicolas G. 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