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Recent data, however, indicate that NGS might even be able to offer a much more detailed appraisal of the fetal genome, including paternal and maternal inheritance of point mutations for mendelian disorders such as \u03b2-thalassaemia. Although these developments are very exciting, in their current form they are still too complex and costly, and will need to be simplified considerably for their optimal translation to the clinic. In this regard, targeted NGS does appear to be a step in the right direction, although this should be seen in the context of ongoing progress with the isolation of fetal cells and with proteomic screening markers.<\/jats:p>","DOI":"10.1017\/s1462399411001852","type":"journal-article","created":{"date-parts":[[2011,5,4]],"date-time":"2011-05-04T08:33:57Z","timestamp":1304498037000},"source":"Crossref","is-referenced-by-count":34,"title":["Determination of fetal chromosome aberrations from fetal DNA in maternal blood: has the challenge finally been 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