{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:59:49Z","timestamp":1747173589356,"version":"3.40.5"},"reference-count":14,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"unspecified","delay-in-days":331,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Prim Health Care Res Dev"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1463423622000718_as1\">\n\t    <jats:title>Aims:<\/jats:title>\n\t    <jats:p>Major lower extremity amputations (MLEAs) are understood to be well recorded in secondary care in England in the Hospital Episode Statistics (HES) database. It is unclear how well MLEAs are recorded in primary care databases.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1463423622000718_as2\">\n\t    <jats:title>Background:<\/jats:title>\n\t    <jats:p>This study compared MLEA event case ascertainment in Clinical Practice Research Datalink (CPRD) to that in HES.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1463423622000718_as3\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>MLEA events were ascertained in CPRD and in HES linkage between 1 January 2010 and 31 December 2019. The number of MLEA events and the number of patients with at least one MLEA in each database were recorded and compared. Individual events were matched between the databases using varying date-matching windows. Reasons for differences in case ascertainment were explored.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1463423622000718_as4\">\n\t    <jats:title>Findings:<\/jats:title>\n\t    <jats:p>In total 23\u00a0262 patients had at least one MLEA record, 8716 (37.5%) had an MLEA record in HES only, 5393 (23.2%) in CPRD only and 9153 (39.4%) in both. Out of a total of 75\u00a0221 events, 13\u00a0071 (62.4%) were recorded in HES only and 44\u00a0151 (81.3%) in CPRD only. 7874 (37.6%) of HES events were recorded in CPRD and 10\u00a0125 (18.6%) of CPRD events were recorded in HES when using the maximum date matching window of 28 days plus the time between admission and procedure. The main reasons for differences in case ascertainment included, re-recordings and miscoding in CPRD.<\/jats:p>\n\t    <jats:p>Compared to HES, MLEAs are poorly recorded in CPRD predominantly due to re-recordings of events and miscoding procedures. CPRD data cannot solely be relied upon to ascertain cases of MLEA; however, HES linkage to CPRD may be useful to obtain medical history of diagnoses, medication and diagnostic tests.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s1463423622000718","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T10:56:24Z","timestamp":1669632984000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Are major lower extremity amputations well recorded in primary care electronic health records?: Insights from primary care electronic health records in England"],"prefix":"10.1017","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9491-6110","authenticated-orcid":false,"given":"Anna","family":"Meffen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-4659","authenticated-orcid":false,"given":"Robert D.","family":"Sayers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8417-9700","authenticated-orcid":false,"given":"Clare L.","family":"Gillies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-7099","authenticated-orcid":false,"given":"Kamlesh","family":"Khunti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-9321","authenticated-orcid":false,"given":"Laura J.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"S1463423622000718_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0442-4"},{"key":"S1463423622000718_ref12","unstructured":"THIN (2022) THIN \u2013 The Health Improvement Network [Online]. Available: https:\/\/www.the-health-improvement-network.com\/?hsLang=en"},{"key":"S1463423622000718_ref9","unstructured":"OPEN-SAFELY (2022) Secure analytics platform for NHS electronic health records [Online]. Available: https:\/\/www.opensafely.org\/"},{"key":"S1463423622000718_ref3","unstructured":"CPRD (2022) Clinical practice research datalink [Online]. Available: https:\/\/cprd.com\/"},{"key":"S1463423622000718_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2012.08.003"},{"key":"S1463423622000718_ref2","unstructured":"CPRD (2022) CPRD Aurum March 2021 dataset [Online]. Available: https:\/\/cprd.com\/cprd-aurum-march-2021"},{"key":"S1463423622000718_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz034"},{"key":"S1463423622000718_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2018.04.017"},{"key":"S1463423622000718_ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-002069"},{"key":"S1463423622000718_ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-053599"},{"key":"S1463423622000718_ref8","unstructured":"NHS-DIGITAL (2022) Hospital Episode Statistics (HES). [Online]. Available: https:\/\/digital.nhs.uk\/data-and-information\/data-tools-and-services\/data-services\/hospital-episode-statistics"},{"key":"S1463423622000718_ref11","unstructured":"QRESEARCH (2022) Generating New Knowledge To Improve Patient Ccare [Online]. Available: https:\/\/www.qresearch.org\/"},{"key":"S1463423622000718_ref13","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.2337\/dc10-0989","article-title":"Changes in the incidence of lower extremity amputations in individuals with and without diabetes in England between 2004 and 2008","volume":"33","author":"Vamos","year":"2010","journal-title":"Diabetes Care"},{"key":"S1463423622000718_ref7","unstructured":"NHS-DIGITAL (2021) General Practice Extraction Service [Online]. Available: https:\/\/digital.nhs.uk\/services\/general-practice-extraction-service#how-gp-collections-work"}],"container-title":["Primary Health Care Research &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1463423622000718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T10:56:30Z","timestamp":1669632990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1463423622000718\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":14,"alternative-id":["S1463423622000718"],"URL":"https:\/\/doi.org\/10.1017\/s1463423622000718","relation":{},"ISSN":["1463-4236","1477-1128"],"issn-type":[{"type":"print","value":"1463-4236"},{"type":"electronic","value":"1477-1128"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e77"}}