{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:44:33Z","timestamp":1793814273582,"version":"4.6.1"},"reference-count":116,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"unspecified","delay-in-days":318,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Prim Health Care Res Dev"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1463423624000215_as1\">\n\t    <jats:title>Aim:<\/jats:title>\n\t    <jats:p>This review aims to identify the mechanistic relationships related to periodontal diseases and its possible association with changes in human milk composition and the composition and function of infants\u2019 gut microbiome.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1463423624000215_as2\">\n\t    <jats:title>Background:<\/jats:title>\n\t    <jats:p>Maternal health conditions, especially inflammatory, are associated with altered human milk composition. It is <jats:italic>not<\/jats:italic> known whether maternal oral inflammatory diseases, including periodontal diseases, deleteriously affect human milk composition.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1463423624000215_as3\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>A narrative review was conducted according to SANRA, the Scale for the Assessment of Narrative Review Articles, guidelines. PubMed, Google Scholar, and Cochrane database of systematic reviews were searched from September 2019 up to December 2023 using keywords such as breast\/human milk, maternal health\/infections, and periodontal diseases. Reference lists of relevant articles were also screened. Our primary outcome of interest was human milk composition (i.e., any changes in macronutrients, immunological components, etc.). Secondary outcomes included changes in human milk microbiome and subsequent changes in the infant gut microbiome. Outcomes were synthesized using a narrative approach where the existing evidence and current literature were summarized. No risk of bias assessment of the studies was performed in this review.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1463423624000215_as4\">\n\t    <jats:title>Findings:<\/jats:title>\n\t    <jats:p>The search yielded no studies investigating the relationship between periodontal diseases in nursing mothers and changes in human milk composition. However, a dose\u2013response relationship exists between the severity of periodontal diseases and the risk of adverse pregnancy outcomes such as preterm birth. Mastitis and diabetes affected milk lipids. Immunoglobulin A (sIgA) was increased in mastitis, whereas reduced concentrations were reported in diabetes. Potential biological pathways through which periodontal diseases can negatively affect human milk composition include the systemic dissemination of inflammatory cytokines like IL-6, PGE2, and tumor necrosis factor (TNF)-\u03b2 that can be up-regulated by bacterial by-products. This biological plausibility needs to be investigated, given the potentially negative impact on the quality of human milk that could be caused by periodontal inflammation.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s1463423624000215","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T13:06:22Z","timestamp":1731589582000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["The unrevealed links: periodontal health, human milk composition, and infant gut microbiome 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