{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:13:10Z","timestamp":1787879590642,"version":"build-2784847793"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"unspecified","delay-in-days":268,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Prim Health Care Res Dev"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1463423625100443_as1\">\n\t    <jats:title>Aim:<\/jats:title>\n\t    <jats:p>This study aimed to assess the impact of oral Fe<jats:sup>+2<\/jats:sup> iron preparations on weight, body composition, metabolic, and appetite parameters in adults undergoing treatment for iron deficiency.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1463423625100443_as2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>In this observational prospective study, a total of 119 patients, aged 18\u201345, initiating Fe<jats:sup>+2<\/jats:sup> iron therapy for iron deficiency within the last month at Family Medicine Outpatient Clinic, were included. Data on sociodemographic variables, health, dietary habits, anthropometric measurements, metabolic parameters, and appetite scores were collected. The Power of Food (PFS), Visual Analogue Scale (VAS), and Three-Factor Eating Questionnaire (TFEQ) were utilized for appetite assessment.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1463423625100443_as3\">\n\t    <jats:title>Findings:<\/jats:title>\n\t    <jats:p>After three months of iron treatment, a statistically significant increase was found in the mean values of Hb, Hct, MCV, ferritin, iron, and transferrin saturation; anthropometric measurements displayed a significant reduction in body weight, body mass index (BMI), fat percentage, waist circumference, hip circumference, and waist\/hip circumference ratios post-treatment. Notably, VAS scores for certain food items decreased, while carbonated drinks VAS score increased. Appetite-related factors, as per PFS, exhibited a significant decrease in PFS factor 1 (food available), PFS factor 2 (food present).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1463423625100443_as4\">\n\t    <jats:title>Conclusions:<\/jats:title>\n\t    <jats:p>In conclusion, our findings indicate that oral Fe<jats:sup>+2<\/jats:sup> iron preparations positively influence the treatment of iron deficiency anaemia by improving haematological parameters and concurrently leading to a significant reduction in body weight, BMI, and appetite scores related to specific food items. The study underscores the multifaceted impact of iron supplementation on both physiological and behavioural aspects, providing valuable insights for optimizing iron deficiency anaemia management.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s1463423625100443","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T06:25:56Z","timestamp":1758867956000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["The effect of ferrous oral iron used in the treatment of iron deficiency on weight gain and appetite in adults: a prospective study"],"prefix":"10.1017","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-8458","authenticated-orcid":false,"given":"Cansu","family":"Alici Yilmaz","sequence":"first","affiliation":[{"name":"Mamak Onur U\u011furlu Family Health Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5153-2184","authenticated-orcid":false,"given":"Duygu","family":"Ayhan Baser","sequence":"additional","affiliation":[{"name":"Hacettepe University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3330-9317","authenticated-orcid":false,"given":"Hilal","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Hacettepe University Faculty of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0363-5645","authenticated-orcid":false,"given":"M. Merve","family":"Tengilimoglu-Metin","sequence":"additional","affiliation":[{"name":"Hacettepe University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"S1463423625100443_ref5","first-page":"123","article-title":"Aile hekimli\u011fi poliklini\u011fine ba\u015fvuran kad\u0131nlarda demir eksikli\u011fi anemisi ve gestasyon \u00f6yk\u00fcs\u00fc ili\u015fkisi","volume":"36","author":"Erdem","year":"2009","journal-title":"Dicle Medical Journal\/Dicle Tip Dergisi"},{"key":"S1463423625100443_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/58.3.339"},{"key":"S1463423625100443_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.3.621"},{"key":"S1463423625100443_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.9.849"},{"key":"S1463423625100443_ref12","first-page":"159","article-title":"Improvements in growth following iron supplementation in young Kenyan school children","volume":"6","author":"Latham","year":"1990","journal-title":"Nutrition (Burbank, Los Angeles County, Calif.)"},{"key":"S1463423625100443_ref17","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/tropej\/fmp011","article-title":"Linear growth in children with iron deficiency anemia before and after treatment","volume":"55","author":"Soliman","year":"2009","journal-title":"Journal of Tropical Pediatrics"},{"key":"S1463423625100443_ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0234209"},{"key":"S1463423625100443_ref23","unstructured":"WHO. (2022) Anaemia in women and children [Online]. Available: https:\/\/www.who.int\/data\/gho\/data\/themes\/topics\/anaemia_in_women_and_children [Accessed 02\/12\/2023 2023]."},{"key":"S1463423625100443_ref1","first-page":"e87","article-title":"Treatment of iron deficiency anemia induces weight loss and improves metabolic parameters","volume":"165","author":"Aktas","year":"2014","journal-title":"La Clinica Terapeutica"},{"key":"S1463423625100443_ref6","first-page":"24","article-title":"Ankara \u00dcniversitesi \u00f6\u011frencilerinde anemi s\u0131kl\u0131\u011f\u0131, etkili fakt\u00f6rler ve beslenme al\u0131\u015fkanl\u0131klar\u0131 \u00fczerine bir ara\u015ft\u0131rma","volume":"30","author":"Erg\u00fclen","year":"2001","journal-title":"Beslenme ve Diyet Dergisi"},{"key":"S1463423625100443_ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117383"},{"key":"S1463423625100443_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92151-2"},{"key":"S1463423625100443_ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23988-x"},{"key":"S1463423625100443_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.05.301"},{"key":"S1463423625100443_ref21","unstructured":"UNU (United Nations University) (2001) W. 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Geneva: World Health Organization; WHO\/NHD\/01.3. https:\/\/cdn.who.int\/media\/docs\/default-source\/2021-dha-docs\/ida_assessment_prevention_control.pdf."},{"key":"S1463423625100443_ref9","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051693"},{"key":"S1463423625100443_ref10","first-page":"615","article-title":"A systematic analysis of global anemia burden from 1990 to 2010","volume":"123","author":"Kassebaum","year":"2014","journal-title":"Blood, The Journal of the American Society of Hematology"},{"key":"S1463423625100443_ref18","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170515123807"},{"key":"S1463423625100443_ref22","first-page":"23","article-title":"Eritrosit hastal\u0131klar\u0131 ve hemoglobin bozukluklar\u0131 tan\u0131 ve tedavi k\u0131lavuzu","author":"\u00dcnal","year":"2011","journal-title":"B\u00f6l\u00fcm III Yeti\u015fkinde Demir Eksikli\u011fi Tan\u0131 ve Tedavi K\u0131lavuzu. Ankara: T\u00fcrk Hematoloji Derne\u011fi"},{"key":"S1463423625100443_ref16","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.29007"},{"key":"S1463423625100443_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2013.01.015"},{"key":"S1463423625100443_ref4","first-page":"30","article-title":"Iron deficiency","volume":"133","author":"Camaschella","year":"2019","journal-title":"Blood, The Journal of the American Society of Hematology"}],"container-title":["Primary Health Care Research &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1463423625100443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T06:25:59Z","timestamp":1758867959000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1463423625100443\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":22,"alternative-id":["S1463423625100443"],"URL":"https:\/\/doi.org\/10.1017\/s1463423625100443","relation":{},"ISSN":["1463-4236","1477-1128"],"issn-type":[{"value":"1463-4236","type":"print"},{"value":"1477-1128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e82"}}