{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:21:44Z","timestamp":1790904104315,"version":"4.1.0"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"1-2","license":[{"start":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T00:00:00Z","timestamp":1175040000000},"content-version":"unspecified","delay-in-days":300,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Anim. Health. Res. Rev."],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>Brucellosis is a zoonotic disease caused by a number of<jats:italic>Brucella<\/jats:italic>species and is characterized by chronic macrophage infection. However, genes that may contribute to intracellular survival of the<jats:italic>Brucella<\/jats:italic>species are not well studied. This review presents, first, genomic islands that are present or absent in various<jats:italic>Brucella<\/jats:italic>species that may help establish<jats:italic>Brucella<\/jats:italic>infection and survival strategies. Second, the alteration in macrophage transcription by<jats:italic>Brucella<\/jats:italic>to permit its long-term survival within this hostile intracellular environment. A large number of macrophage gene transcripts are altered following<jats:italic>Brucella<\/jats:italic>infection indicating that<jats:italic>Brucella<\/jats:italic>is not a silent invader of host cells. Macrophage transcript levels associated with inflammation, apoptosis, signal transduction and vesicular intracellular trafficking are altered during<jats:italic>Brucella<\/jats:italic>infection, and likely contribute to intracellular survival of<jats:italic>Brucella<\/jats:italic>. Lastly, the host\u2013pathogen interaction events associated with<jats:italic>Brucella<\/jats:italic>infection in living mice visualized in real-time using biophotonic imaging. Mice are often used to evaluate<jats:italic>Brucella<\/jats:italic>infections; however,<jats:italic>Brucella<\/jats:italic>dissemination and pathogenesis is poorly understood in mice. Biophotonic imaging of<jats:italic>Brucella<\/jats:italic>infections revealed sites of bacterial localization similar to human infections and different patterns of infection by attenuated or virulent<jats:italic>Brucella<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s146625230700117x","type":"journal-article","created":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T09:45:54Z","timestamp":1175075154000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":25,"title":["<i>Brucella<\/i>: functional genomics and host\u2013pathogen 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