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Rev."],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Pasteurella multocida<\/jats:italic>\n                    is a pathogenic Gram-negative bacterium that has been classified into three subspecies, five capsular serogroups and 16 serotypes.\n                    <jats:italic>P. multocida<\/jats:italic>\n                    serogroup A isolates are bovine nasopharyngeal commensals, bovine pathogens and common isolates from bovine respiratory disease (BRD), both enzootic calf pneumonia of young dairy calves and shipping fever of weaned, stressed beef cattle.\n                    <jats:italic>P. multocida<\/jats:italic>\n                    A:3 is the most common serotype isolated from BRD, and these isolates have limited heterogeneity based on outer membrane protein (OMP) profiles and ribotyping. Development of\n                    <jats:italic>P. multocida<\/jats:italic>\n                    -induced pneumonia is associated with environmental and stress factors such as shipping, co-mingling, and overcrowding as well as concurrent or predisposing viral or bacterial infections. Lung lesions consist of an acute to subacute bronchopneumonia that may or may not have an associated pleuritis. Numerous virulence or potential virulence factors have been described for bovine respiratory isolates including adherence and colonization factors, iron-regulated and acquisition proteins, extracellular enzymes such as neuraminidase, lipopolysaccharide, polysaccharide capsule and a variety of OMPs. Immunity of cattle against respiratory pasteurellosis is poorly understood; however, high serum antibodies to OMPs appear to be important for enhancing resistance to the bacterium. Currently available\n                    <jats:italic>P. multocida<\/jats:italic>\n                    vaccines for use in cattle are predominately traditional bacterins and a live streptomycin-dependent mutant. The field efficacy of these vaccines is not well documented in the literature.\n                  <\/jats:p>","DOI":"10.1017\/s1466252307001399","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T08:45:28Z","timestamp":1201164328000},"page":"129-150","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":195,"title":["<i>Pasteurella multocida<\/i>\n                    and bovine respiratory disease"],"prefix":"10.1017","volume":"8","author":[{"given":"S.\u00a0M.","family":"Dabo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u00a0D.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u00a0W.","family":"Confer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2008,1,24]]},"reference":[{"key":"S1466252307001399_ref262","first-page":"585","article-title":"Differentiation of Pasteurella multocida subspecies multocida isolates from the respiratory system of pigs by using polymerase chain reaction fingerprinting technique","volume":"43","author":"Zucker","year":"1996","journal-title":"Zentralblatt f\u00fcr Veterin\u00e4rmedizin [B]"},{"key":"S1466252307001399_ref259","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1128\/JCM.30.6.1518-1524.1992","article-title":"Comparison of DNA fingerprints and somatic serotypes of serogroup B and E Pasteurella multocida isolates","volume":"30","author":"Wilson","year":"1992","journal-title":"Journal of Clinical Microbiology"},{"key":"S1466252307001399_ref258","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-33-4-217"},{"key":"S1466252307001399_ref257","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1128\/IAI.63.5.1703-1709.1995","article-title":"Extracellular neuraminidase production by a Pasteurella multocida A:3 strain associated with bovine pneumonia","volume":"63","author":"White","year":"1995","journal-title":"Infection and Immunity"},{"key":"S1466252307001399_ref256","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1993.tb01729.x"},{"key":"S1466252307001399_ref255","doi-asserted-by":"publisher","DOI":"10.1177\/104063870401600510"},{"key":"S1466252307001399_ref252","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1128\/JCM.32.3.725-731.1994","article-title":"A 4-year survey of antimicrobial susceptibility trends for isolates from cattle with bovine respiratory disease in North America","volume":"32","author":"Watts","year":"1994","journal-title":"Journal of Clinical Microbiology"},{"key":"S1466252307001399_ref251","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1097(03)00437-3"},{"key":"S1466252307001399_ref250","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1128\/JB.180.22.6013-6022.1998","article-title":"Haemophilus ducreyi secretes a filamentous hemagglutinin-like protein [In Process Citation]","volume":"180","author":"Ward","year":"1998","journal-title":"Journal of Bacteriology"},{"key":"S1466252307001399_ref248","doi-asserted-by":"publisher","DOI":"10.2307\/1592072"},{"key":"S1466252307001399_ref247","article-title":"Dairy calf management, morbidity and mortality in Ontario Holstein herds. 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