{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:43:51Z","timestamp":1769262231551,"version":"3.49.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T00:00:00Z","timestamp":1308096000000},"content-version":"unspecified","delay-in-days":14,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Anim. Health. Res. Rev."],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the first half of the twentieth century, widespread regulatory efforts to control cattle brucellosis due to <jats:italic>Brucella abortus<\/jats:italic> in the Union of Soviet Socialist Republics were essentially non-existent, and control was limited to selective test and slaughter of serologic agglutination reactors. By the 1950s, 2\u20133 million cattle were being vaccinated annually with the strain 19 vaccine, but because this vaccine induced strong, long-term titers on agglutination tests that interfered with identification of cattle infected with field strains of <jats:italic>B. abortus,<\/jats:italic> its use in cattle was discontinued in 1970. Soviet scientists then began a comprehensive program of research to identify vaccines with high immunogenicity, weak responses on agglutination tests and low pathogenicity in humans, as a foundation for widespread control of cattle brucellosis. While several new vaccines that induced weak or no responses on serologic agglutination tests were identified by experiments in guinea pigs and cattle, a large body of experimental and field studies suggested that the smooth\u2013rough strain SR82 vaccine combined the desired weak agglutination test responses with comparatively higher efficacy against brucellosis. In 1974, prior to widespread use of strain SR82 vaccine, over 5300 cattle farms across the Russian Federation were known to be infected with <jats:italic>B. abortus<\/jats:italic>. By January 2008, only 68 cattle farms in 18 regions were known to be infected with <jats:italic>B. abortus<\/jats:italic>, and strain SR82 continues to be the most widely and successfully used vaccine in many regions of the Russian Federation.<\/jats:p>","DOI":"10.1017\/s1466252311000028","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T13:31:50Z","timestamp":1308144710000},"page":"113-121","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":23,"title":["A live vaccine from <i>Brucella abortus<\/i> strain 82 for control of cattle brucellosis in the Russian Federation"],"prefix":"10.1017","volume":"12","author":[{"given":"Arkady V.","family":"Ivanov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin M.","family":"Salmakov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven C.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn E.","family":"Plumb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2011,6,15]]},"reference":[{"key":"S1466252311000028_ref020","first-page":"125","article-title":"Study of immunity in guinea pigs and cattle, immunized with vaccine strains 19 and 82","volume":"97","author":"Salmakov","year":"1966","journal-title":"Uchenye Zapiski Kazanskogo Vetinstituta"},{"key":"S1466252311000028_ref011","first-page":"48","article-title":"Study of the stable properties of vaccine strain 82","volume":"129","author":"Krasheninnikova","year":"1978","journal-title":"Uchenye Zapiski Kazanskogo Vetinstituta"},{"key":"S1466252311000028_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.03.050"},{"key":"S1466252311000028_ref014","unstructured":"Nikiforov IP , Shumilov KV , Klimanov AI , Shikhaleev YuN , Kalmykov VV and Solntseva EN (1993). Study of the adaptability, virulence, and possible migration of strain 75\u201379A. In: Collection of Scientific Works of the Institute of Experimental Veterinary Science of Siberia and the Far East. Novosibirsk, Elsevier, pp. 66\u201373."},{"key":"S1466252311000028_ref012","first-page":"48","article-title":"Results of verifying the properties of separate batches of the dry live brucellosis vaccine from strain 82","volume":"135","author":"Mikhailov","year":"1980","journal-title":"Research Papers KVI"},{"key":"S1466252311000028_ref008","first-page":"94","article-title":"Results of studying Brucella vaccine strains","volume":"23","author":"Ivanov","year":"1977","journal-title":"Papers from the Russian National Center for Quality and Standardization of Animal Drugs and Food (VGNKI)"},{"key":"S1466252311000028_ref004","first-page":"84","article-title":"Results of using the brucellosis vaccine from the weakly agglutinogenic strain 82 in cattle","volume":"135","author":"Bazalei","year":"1980","journal-title":"The Kazan Veterinary Institute"},{"key":"S1466252311000028_ref002","unstructured":"Avilov VM (1997). Epizootological oversight for brucellosis of cattle in a modern environment. 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Ph.D. thesis in Veterinary Sciences, All-Russian Research Veterinary Institute, Kazan, Russia."},{"key":"S1466252311000028_ref013","unstructured":"Nikiforov IP , Shumilov KV and Dimov SK (1996). Results of studying the abortifacient properties of vaccine strain B. abortus 75\u201379AB under farm-scale conditions. 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Identifying new Brucella vaccine strains. Synopsis of a Thesis, Candidate in Veterinary Sciences, Kazan, p. 20."},{"key":"S1466252311000028_ref017","unstructured":"Oshchepkov VG (2007). Natural and specific resistance of humans and animals in Siberia. 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