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Acquiring sufficient levels of some of these metals, particularly iron, manganese and zinc, is especially challenging in the mammalian host, where sequestration of these micronutrients is a well-documented component of both the innate and acquired immune responses. This review describes the<jats:italic>Brucella<\/jats:italic>metal transporters that have been shown to play critical roles in the virulence of these bacteria in experimental and natural hosts.<\/jats:p>","DOI":"10.1017\/s1466252312000047","type":"journal-article","created":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T13:40:44Z","timestamp":1337953244000},"page":"10-20","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":28,"title":["Metal acquisition and virulence in<i>Brucella<\/i>"],"prefix":"10.1017","volume":"13","author":[{"suffix":"II","given":"R. 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