{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T01:43:46Z","timestamp":1781055826969,"version":"3.54.1"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T00:00:00Z","timestamp":1468800000000},"content-version":"unspecified","delay-in-days":47,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Anim. Health. Res. Rev."],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infectious bovine keratoconjunctivitis (IBK) is a common and important disease of calves. Without effective vaccines, antibiotic therapy is often implemented to minimize the impact of IBK. This review updates a previously published systematic review regarding comparative efficacy for antibiotic treatments of IBK. Available years of Centre for Biosciences and Agriculture International and MEDLINE databases were searched, including non-English results. Also searched were the American Association of Bovine Practitioners and World Buiatrics Congress conference proceedings from 1996 to 2016, reviews since 2013, reference lists from relevant trials, and U.S. Food and Drug Administration New Animal Drug Application summaries. Eligible studies assessed antibiotic treatment of naturally-occurring IBK in calves randomly allocated to group at the individual level. Outcomes of interest were clinical score, healing time, unhealed ulcer risk, and ulcer surface area. A mixed-effects model comparing active drug with placebo was employed for all outcomes. Heterogeneity was assessed visually and using Cochran's Q-test. Thirteen trials assessing nine treatments were included. Compared with placebo, most antibiotic treatments were effective. There was evidence that the treatment effect differed by day of outcome measurement. Visually, the largest differences were observed 7\u201314 days post-treatment. These results indicate improved IBK healing with many antibiotics and suggest the need for randomized trials comparing different antibiotic treatments.<\/jats:p>","DOI":"10.1017\/s1466252316000050","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T10:06:00Z","timestamp":1468836360000},"page":"60-75","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":22,"title":["A systematic review and meta-analysis of the antibiotic treatment for infectious bovine keratoconjunctivitis: an update"],"prefix":"10.1017","volume":"17","author":[{"given":"J. N.","family":"Cullen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Totton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Dzikamunhenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Coetzee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,7,18]]},"reference":[{"key":"S1466252316000050_ref39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00536.x"},{"key":"S1466252316000050_ref29","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1875"},{"key":"S1466252316000050_ref41","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4002"},{"key":"S1466252316000050_ref45","first-page":"196","article-title":"Efficacy of different dosage levels and administration routes of tilmicosin in a natural outbreak of infectious bovine keratoconjunctivitis (pinkeye)","volume":"3","author":"Zielinski","year":"2002","journal-title":"Veterinary Therapeutics"},{"key":"S1466252316000050_ref30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"S1466252316000050_ref10","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2004.65.1185"},{"key":"S1466252316000050_ref14","unstructured":"Freedom of Information Summary (2007). NADA 141-244 \u2013 DRAXXIN Injectable Solution. [Available online at http:\/\/www.fda.gov\/downloads\/animalveterinary\/products\/approvedanimaldrugproducts\/foiadrugsummaries\/ucm051495.pdf]."},{"key":"S1466252316000050_ref36","unstructured":"R Core Team (2015). R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing."},{"key":"S1466252316000050_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2013.01.038"},{"key":"S1466252316000050_ref16","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.1.100"},{"key":"S1466252316000050_ref44","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"S1466252316000050_ref12","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2460\/ajvr.1989.50.06.838","article-title":"Survival analysis for evaluation of corneal ulcer healing times in calves with naturally acquired infectious bovine keratoconjunctivitis","volume":"50","author":"Edmondson","year":"1989","journal-title":"American Journal of Veterinary Research"},{"key":"S1466252316000050_ref3","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.2460\/javma.1995.206.08.1200","article-title":"Effect of penicillin or penicillin and dexamethasone in cattle with infectious bovine keratoconjunctivitis","volume":"206","author":"Allen","year":"1995","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"S1466252316000050_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.05.082"},{"key":"S1466252316000050_ref1","first-page":"100","article-title":"Two treatments for bovine infections keratoconjunctivitis Evaluacion de dos regimenes de tratamiento antibiotico topico, para Queratoconjuntivitis Infecciosa Bovina","volume":"83","author":"Abdala","year":"2002","journal-title":"Revista de Medicina Veterinaria (Buenos Aires)"},{"key":"S1466252316000050_ref31","doi-asserted-by":"publisher","DOI":"10.1017\/S146625230700120X"},{"key":"S1466252316000050_ref9","article-title":"A randomized, controlled, blinded trial assessing the association between infectious bovine keratoconjunctivitis incidence and a commercial Moraxella bovis vaccine in beef calves","author":"Cullen","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"S1466252316000050_ref13","first-page":"163","article-title":"Efficacy of tulathromycin in a outbreak of infectious bovine keratoconjunctivitis","volume":"16","author":"Emarcora","year":"2010","journal-title":"Large Animal Review"},{"key":"S1466252316000050_ref33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.00803.x"},{"key":"S1466252316000050_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19961230)15:24<2733::AID-SIM562>3.0.CO;2-0"},{"key":"S1466252316000050_ref5","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.64333-0"},{"key":"S1466252316000050_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1998.tb02120.x"},{"key":"S1466252316000050_ref42","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1970.10481069"},{"key":"S1466252316000050_ref34","unstructured":"Pfizer Animal Health (2008). Efficacy of DRAXXIN (tulathromycin) Injectable solution for treatment of naturally occurring infectious bovine keratoconjunctivitis associated with Moraxella bovis in beef and airy calves. [Available online at https:\/\/www.zoetisus.com\/\\_locale-assets\/myresources\/drx08001-pinkeye-tb.pdf]."},{"key":"S1466252316000050_ref40","first-page":"219","article-title":"Efficacy of intrapalpebral and intramuscular application of oxytetracycline in a natural outbreak of infectious bovine kertoconjunctivitis (IBK) in calves","volume":"114","author":"Starke","year":"2007","journal-title":"DTW. Deutsche tierarztliche Wochenschrift"},{"key":"S1466252316000050_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2009.10.008"},{"key":"S1466252316000050_ref11","doi-asserted-by":"crossref","first-page":"560","DOI":"10.2460\/javma.1998.212.04.560","article-title":"Combined parenteral and oral administration of oxytetracycline for control of infectious bovine keratoconjunctivitis","volume":"212","author":"Eastman","year":"1998","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"S1466252316000050_ref17","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.2460\/javma.1988.192.10.1415","article-title":"Topically applied furazolidone or parenterally administered oxytetracycline for the treatment of infectious bovine keratoconjunctivitis","volume":"192","author":"George","year":"1988","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"S1466252316000050_ref28","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.4.557"},{"key":"S1466252316000050_ref8","unstructured":"Cosgrove SB , Simmons RD , Johnson JC and Varma KJ (1998). In vivo and in vitro efficacy of Nuor (orfenicol) in the treatment of infectious bovine keratoconjunctivitis. Schering-plough Animal Health Nuor: new therapeutic applications. In: Proceedings of a Symposium Held in Conjunction with the XX World Buiatrics Congress, p. 514."},{"key":"S1466252316000050_ref37","first-page":"6","article-title":"Effect of early treatment with parenteral long-acting oxytetracycline on performance of beef calves with acute eye lesions","volume":"16","author":"Roeder","year":"1995","journal-title":"Agri-Practice"},{"key":"S1466252316000050_ref43","doi-asserted-by":"publisher","DOI":"10.2527\/jas1974.3861179x"},{"key":"S1466252316000050_ref7","first-page":"34","article-title":"Clinical evaluation of infectious bovine keratoconjunctivitis after treatment with long acting oxytetracycline La keratoconjonctivite infectieuse bovine: evaluation clinique apres traitement a l'oxytetracycline longue action","volume":"7","author":"Chadli","year":"1992","journal-title":"Maghreb Veterinaire"},{"key":"S1466252316000050_ref2","first-page":"487","article-title":"Infectious bovine keratoconjunctivitis: a review of cases in clinical practice","volume":"26","author":"Alexander","year":"2010","journal-title":"Veterinary Clinics of North America: Food Animal Practice"},{"key":"S1466252316000050_ref21","unstructured":"Gotelli NJ , Hart EM and Ellison AM (2015). EcoSimR: Null model analysis for ecological data \u2013 version 0.1.0. [Available online at http:\/\/github.com\/gotellilab\/EcoSimR]."},{"key":"S1466252316000050_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/9780470712184"},{"key":"S1466252316000050_ref4","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.216.62"},{"key":"S1466252316000050_ref20","first-page":"573","article-title":"A comparison of the efficacy of orfenicol and oxytetracycline in the treatment of naturally occurring infectious bovine keratoconjunctivitis","volume":"55","author":"Gokce","year":"2002","journal-title":"Irish Veterinary Journal"},{"key":"S1466252316000050_ref18","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.2460\/javma.1984.185.10.1206","article-title":"Antibiotic treatment of Moraxella bovis infection in cattle","volume":"185","author":"George","year":"1984","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"S1466252316000050_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6632"},{"key":"S1466252316000050_ref27","unstructured":"J\u00f8rgensen E and Pedersen AR (1998). How to obtain those nasty standard errors from transformed data-and why they should not be used. [Available online at http:\/\/gbi.agrsci.dk\/~ejo\/publications\/dinapig\/intrep7.pdf]."},{"key":"S1466252316000050_ref35","first-page":"219","article-title":"Clinical efficacy of parenteral vs ophthalmic orfenicol for the treatment of infectious bovine keratoconjunctivitis","volume":"41","author":"Quesada","year":"2010","journal-title":"Veterinaria Mexico"},{"key":"S1466252316000050_ref19","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.2460\/ajvr.1989.50.07.1170","article-title":"Effectiveness of two benzathine cloxacillin formulations for treatment of naturally occuring infectious bovine keratoconjunctivitis","volume":"50","author":"George","year":"1989","journal-title":"American Journal of Veterinary Research"},{"key":"S1466252316000050_ref38","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-7-200804010-00011"},{"key":"S1466252316000050_ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2008.00347.x"}],"container-title":["Animal Health Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1466252316000050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T01:55:49Z","timestamp":1749002149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1466252316000050\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S1466252316000050"],"URL":"https:\/\/doi.org\/10.1017\/s1466252316000050","relation":{},"ISSN":["1466-2523","1475-2654"],"issn-type":[{"value":"1466-2523","type":"print"},{"value":"1475-2654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2016\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}