{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:34:53Z","timestamp":1778567693694,"version":"3.51.4"},"reference-count":6,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2006,4,13]],"date-time":"2006-04-13T00:00:00Z","timestamp":1144886400000},"content-version":"unspecified","delay-in-days":133,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>Malignancy-associated primary thiamine deficiency has been documented \nin several experimental tumors, clinical case reports, and in patients \nwith fast growing malignancies. We report a terminally ill cancer patient \nwho developed delirium. Close examination of the patient demonstrated that \ndelirium was caused by thiamine deficiency, although she had been \nconsuming an average of 990 cal\/day for the past 3 weeks. \nMalabsorption or consumption by the tumor was considered the mechanism of \nthiamine deficiency. Early recognition and subsequent treatment resulted \nin successful palliation of delirium. In terminally ill cancer patients, \nclinicians must remain aware of the possibility of Wernicke's \nencephalopathy, when the patients develop unexplained delirium, even if \nthe patient has been consuming adequate amounts of food. Early \nintervention may correct the symptoms and prevent irreversible brain \ndamage, and the quality of life for the patient may improve.<\/jats:p>","DOI":"10.1017\/s1478951505050509","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T15:28:32Z","timestamp":1208791712000},"page":"333-335","source":"Crossref","is-referenced-by-count":20,"title":["Development of Wernicke encephalopathy in a terminally ill cancer \npatient consuming an adequate diet: A case report and review of the \nliterature"],"prefix":"10.1017","volume":"3","author":[{"given":"SUZU","family":"YAE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHIGEKO","family":"OKUNO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HIDEKI","family":"ONISHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHIAKI","family":"KAWANISHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2006,4,13]]},"reference":[{"key":"S1478951505050509_ref005","doi-asserted-by":"crossref","unstructured":"Seligmann, H. , Levi, R. , Konijn, A.M. ,et al.(2001).Thiamine deficiency in patients with B-chronic lymphocyticleukaemia: A pilot study.Postgraduate Medical Journal,77,582\u2013585","DOI":"10.1136\/pmj.77.911.582"},{"key":"S1478951505050509_ref001","doi-asserted-by":"crossref","unstructured":"Francis, J. , Martin, D. , & Kapoor, W.N. (1990).A prospective study of delirium in hospitalized elderly.JAMA,263,1097\u20131101.","DOI":"10.1001\/jama.1990.03440080075027"},{"key":"S1478951505050509_ref006","doi-asserted-by":"crossref","unstructured":"van Zaanen, H.C.T. & van der Lelie, J. (1992).Thiamine deficiency in hematologic malignant tumors.Cancer,69,1710\u20131713.","DOI":"10.1002\/1097-0142(19920401)69:7<1710::AID-CNCR2820690711>3.0.CO;2-D"},{"key":"S1478951505050509_ref002","doi-asserted-by":"crossref","unstructured":"Hoyumpa, A.M. (1986).Mechanisms of vitamin deficiencies in alcoholism.Alcoholism: Clinical and Experimental Research,10,573\u2013581.","DOI":"10.1111\/j.1530-0277.1986.tb05147.x"},{"key":"S1478951505050509_ref004","unstructured":"Onishi, H. , Kawanishi, C. , Onose, M. ,et al.(2004).Successful treatment of Wernicke encephalopathy in terminally illcancer patients: Report of 3 cases and review of the literature.Supportive Care in Cancer,12,604\u2013608."},{"key":"S1478951505050509_ref003","doi-asserted-by":"crossref","unstructured":"Macleod, A.D. (2000).Wernicke's encephalopathy and terminal cancer: Casereport.Palliative Medicine,14,217\u2013218.","DOI":"10.1191\/026921600668593115"}],"container-title":["Palliative and Supportive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1478951505050509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T19:38:27Z","timestamp":1556912307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1478951505050509\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S1478951505050509"],"URL":"https:\/\/doi.org\/10.1017\/s1478951505050509","relation":{},"ISSN":["1478-9515","1478-9523"],"issn-type":[{"value":"1478-9515","type":"print"},{"value":"1478-9523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}