{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T09:40:13Z","timestamp":1704793213082},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2008,11,13]],"date-time":"2008-11-13T00:00:00Z","timestamp":1226534400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec id=\"S147895150800059X_sec1\"><jats:title>Objective:<\/jats:title><jats:p>Oral mucositis (OM) is a frequently encountered problem as a complication of cancer treatment. We investigated whether daily washings with colchicine solution improved mucositis in patients with hematological malignancies undergoing chemotherapy.<\/jats:p><\/jats:sec><jats:sec id=\"S147895150800059X_sec2\"><jats:title>Methods:<\/jats:title><jats:p>This study was a one-arm, nonrandomized clinical trial that used a historical control group. Patients were included in the study from the first day of mucositis and followed up until discharge. Patients received 2\u00a0mg colchicine mouthwashes daily for 5 days or saline solution. OM was assessed once daily until symptom resolution, using the WHO grading scale of 0\u20134 and a visual analogue scale. We determined that at least 40 patients in the colchicine group would be needed to detect a 20% difference in the duration of OM between Groups A and B, with a 95% confidence level and a power of 80%.<\/jats:p><\/jats:sec><jats:sec id=\"S147895150800059X_sec3\"><jats:title>Results:<\/jats:title><jats:p>82 patients were included in the final analysis, 40 in the colchicine group and 42 in the control group. Median duration of OM was significantly different among groups; 9days (range 1\u201317days) for the control group versus 6days (range 3\u201313days) for those exposed to colchicine mouthwash (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.028). The median days of regression of mucosal lesions were significantly different (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.047) among the control group (7 days [range 3\u201320]) compared to the colchicine group (4 days [range 2\u201314]).<\/jats:p><\/jats:sec><jats:sec id=\"S147895150800059X_sec4\"><jats:title>Significance of results:<\/jats:title><jats:p>Although our findings suggest that colchicine mouthwash is helpful in reducing the severity and duration of chemotherapy-induced OM, randomized trials are needed to confirm these results.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s147895150800059x","type":"journal-article","created":{"date-parts":[[2008,11,13]],"date-time":"2008-11-13T08:46:43Z","timestamp":1226566003000},"page":"371-376","source":"Crossref","is-referenced-by-count":6,"title":["Colchicine mouth washings to improve oral mucositis in patients with hematological malignancies: A clinical trial"],"prefix":"10.1017","volume":"6","author":[{"given":"Andr\u00e9s \u00c1vila","family":"Garavito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s Felipe","family":"Cardona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic","family":"Reveiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Ospina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Yepes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vannesa","family":"Ospina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,11,13]]},"reference":[{"key":"S147895150800059X_ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00614_1.x"},{"key":"S147895150800059X_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11671"},{"key":"S147895150800059X_ref13","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.125.433"},{"key":"S147895150800059X_ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1988.01860180085037"},{"key":"S147895150800059X_ref16","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0016-5085(80)90767-2","article-title":"Radiation esophagitis in the opossum: Radioprotection with indomethacin","volume":"78","author":"Northway","year":"1980","journal-title":"Gastroenterology"},{"key":"S147895150800059X_ref2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5070\/D30N02G93T","article-title":"Colchicine and benzathine penicillin in the treatment of Behcet disease: A case comparative study","volume":"11","author":"Al-Waiz","year":"2005","journal-title":"Dermatology Online Journal"},{"key":"S147895150800059X_ref9","first-page":"1365","article-title":"Recurrent aphthous stomatitis: Treatment with colchicine. An open trial of 54 cases","volume":"129","author":"Fontes","year":"2002","journal-title":"Annales de Dermatologie et de Venereologie"},{"key":"S147895150800059X_ref14","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.123.1023"},{"key":"S147895150800059X_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0050-9"},{"key":"S147895150800059X_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/neh129"},{"key":"S147895150800059X_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010815)92:4<875::AID-CNCR1396>3.0.CO;2-1"},{"key":"S147895150800059X_ref23","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500802"},{"key":"S147895150800059X_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650440024010"},{"key":"S147895150800059X_ref4","first-page":"36","article-title":"Prevenci\u00f3n y tratamiento de la mucositis oral inducida por quimio y radioterapia (Prevention and treatment of oral mucositis induced by chemotherapy and radiotherapy)","volume":"41","author":"\u00c1vila","year":"2000","journal-title":"Revue Colombiana Cancerologia (Colombian Cancer Review)"},{"key":"S147895150800059X_ref28","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000978.pub2"},{"key":"S147895150800059X_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70211-X"},{"key":"S147895150800059X_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(99)00033-0"},{"key":"S147895150800059X_ref25","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.279"},{"key":"S147895150800059X_ref22","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1318"},{"key":"S147895150800059X_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(85)80005-0"},{"key":"S147895150800059X_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00558-1"},{"key":"S147895150800059X_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0058-1"},{"key":"S147895150800059X_ref17","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1634\/theoncologist.3-6-446","article-title":"Mucositis: Its occurrence, consequences, and treatment in the oncology setting","volume":"3","author":"Pico","year":"1998","journal-title":"Oncologist"},{"key":"S147895150800059X_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199406000-00014"},{"key":"S147895150800059X_ref27","article-title":"Interventions for treating oral mucositis for patients with cancer receiving treatment","author":"Worthington","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S147895150800059X_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-004-0674-6"},{"key":"S147895150800059X_ref21","doi-asserted-by":"publisher","DOI":"10.1054\/bjom.2000.0468"},{"key":"S147895150800059X_ref5","doi-asserted-by":"publisher","DOI":"10.1081\/BIP-120028514"}],"container-title":["Palliative and Supportive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S147895150800059X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T20:10:51Z","timestamp":1632168651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S147895150800059X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,13]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S147895150800059X"],"URL":"https:\/\/doi.org\/10.1017\/s147895150800059x","relation":{},"ISSN":["1478-9515","1478-9523"],"issn-type":[{"value":"1478-9515","type":"print"},{"value":"1478-9523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,13]]}}}