{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:38:13Z","timestamp":1776742693425,"version":"3.51.2"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1478951513001260_sec1\"><jats:title>Objective:<\/jats:title><jats:p>Consistent use of imatinib is critical for treatment success in chronic myeloid leukemia, yet perfect adherence to the prescribed clinical regimen is reported to be as low as 14%. This study aimed to understand patients' experiences of chronic myeloid leukemia with a qualitative approach, including identified facilitators and barriers to adherence, drawing on patients' and health professionals' perspectives, recording comments made by patients and health professionals involved with the same treatment team.<\/jats:p><\/jats:sec><jats:sec id=\"S1478951513001260_sec2\"><jats:title>Method:<\/jats:title><jats:p>We recruited patients with chronic myeloid leukemia prescribed imatinib therapy and health professionals involved in their treatment from a specialized cancer center. Semi-structured qualitative interviews were recorded, transcribed, and manually analyzed using interpretive phenomenological analysis. Recruitment ceased upon saturation, with 16 patients and 10 health professionals (hematologists<jats:italic>n<\/jats:italic>\u00a0=\u00a04, nurses<jats:italic>n<\/jats:italic>\u00a0=\u00a03, pharmacists<jats:italic>n<\/jats:italic>\u00a0=\u00a03).<\/jats:p><\/jats:sec><jats:sec id=\"S1478951513001260_sec3\"><jats:title>Results:<\/jats:title><jats:p>Twelve patients reported at least one instance of nonadherence. Reasons for unintentional nonadherence included forgetfulness related to variations of routine and doctor\u2013patient communication issues. Reasons for intentional nonadherence included desires to reduce dose-dependent side effects and insufficient support. Patients who reported higher nonadherence rates felt complacent following periods of sustained disease control or had received conflicting advice regarding nonadherence. Health professionals had difficulty in accurately evaluating medication adherence due to a lack of reliable measures, utilizing patient self-report and manifestations of suboptimal disease control to guide assessments.<\/jats:p><\/jats:sec><jats:sec id=\"S1478951513001260_sec4\"><jats:title>Significance of Results:<\/jats:title><jats:p>Adherence issues persist throughout the course of treatment. While high patient-reported nonadherence rates were recorded, health professionals were often unaware of the complex causes, compounded by an inadequacy of adherence assessment tools. Some patients reported nonadherence events because of insufficient education or lack of access to prompt medical guidance. These issues should be addressed to improve clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1478951513001260","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T15:11:30Z","timestamp":1392304290000},"page":"255-263","source":"Crossref","is-referenced-by-count":25,"title":["Lack of congruence between patients' and health professionals' perspectives of adherence to imatinib therapy in treatment of chronic myeloid leukemia: A qualitative study"],"prefix":"10.1017","volume":"13","author":[{"given":"Simon","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond","family":"Chee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Ugalde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis","family":"Butow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Seymour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penelope","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"S1478951513001260_ref23","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.11.026"},{"key":"S1478951513001260_ref38","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.96.4.569"},{"key":"S1478951513001260_ref4","doi-asserted-by":"publisher","DOI":"10.4324\/9780203413081"},{"key":"S1478951513001260_ref39","doi-asserted-by":"publisher","DOI":"10.1097\/00000446-200106000-00019"},{"key":"S1478951513001260_ref10","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.111.3.455"},{"key":"S1478951513001260_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.10.017"},{"key":"S1478951513001260_ref1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.349"},{"key":"S1478951513001260_ref12","article-title":"A global retrospective and physician-based analysis of adherence to tyrosine kinase inhibitor (TKI) therapies for chronic myeloid leukemia (CML)","volume":"116","author":"Guilhot","year":"2010","journal-title":"ASH Annual Meeting Abstracts"},{"key":"S1478951513001260_ref31","first-page":"56","article-title":"Patient adherence and persistence with oral anticancer treatment","volume":"59","author":"Ruddy","year":"2009","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"S1478951513001260_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmp035"},{"key":"S1478951513001260_ref18","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.8.1.99"},{"key":"S1478951513001260_ref25","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-196543"},{"key":"S1478951513001260_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2009.07.038"},{"key":"S1478951513001260_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-008-0515-0"},{"key":"S1478951513001260_ref32","volume-title":"Adherence to long-term therapies: Evidence for action","author":"Sabate","year":"2003"},{"key":"S1478951513001260_ref7","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.348"},{"key":"S1478951513001260_ref8","doi-asserted-by":"crossref","unstructured":"Efficace F. , Rosti G. , Cottone F. , (2013). Profiling chronic myeloid leukemia patients reporting intentional and unintentional non-adherence to lifelong therapy with tyrosine kinase inhibitors. Leukemia Research [Epub ahead of print]. http:\/\/dx.doi.org\/10.1016\/j.leukres.2013.07.003.","DOI":"10.1016\/j.leukres.2013.07.003"},{"key":"S1478951513001260_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-004-0677-3"},{"key":"S1478951513001260_ref14","article-title":"Interventions for enhancing medication adherence","volume":"16","author":"Haynes","year":"2008","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S1478951513001260_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61165-9"},{"key":"S1478951513001260_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/1363459308101806"},{"key":"S1478951513001260_ref13","doi-asserted-by":"publisher","DOI":"10.1188\/03.CJON.S6.21-24"},{"key":"S1478951513001260_ref27","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.03.050"},{"key":"S1478951513001260_ref17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-309807"},{"key":"S1478951513001260_ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0838-3"},{"key":"S1478951513001260_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2012.04.002"},{"key":"S1478951513001260_ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2010.01212.x"},{"key":"S1478951513001260_ref11","doi-asserted-by":"publisher","DOI":"10.2147\/JMDH.S21111"},{"key":"S1478951513001260_ref16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.1_suppl.65S"},{"key":"S1478951513001260_ref35","volume-title":"Interpretive phenomenological analysis: Theory method and research","author":"Smith","year":"2009"},{"key":"S1478951513001260_ref30","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199808000-00004"},{"key":"S1478951513001260_ref5","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.88"},{"key":"S1478951513001260_ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"S1478951513001260_ref37","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-3-259"},{"key":"S1478951513001260_ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.0779"},{"key":"S1478951513001260_ref26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050100"},{"key":"S1478951513001260_ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-004325"},{"key":"S1478951513001260_ref33","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s00520-002-0420-x","article-title":"How oncologists discuss complementary therapy use with their patients: An audio-tape audit","volume":"11","author":"Schofield","year":"2003","journal-title":"Supportive Care in Cancer"},{"key":"S1478951513001260_ref36","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.18.2.151"},{"key":"S1478951513001260_ref22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3087"},{"key":"S1478951513001260_ref40","doi-asserted-by":"publisher","DOI":"10.1188\/10.CJON.461-466"}],"container-title":["Palliative and Supportive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1478951513001260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T10:21:26Z","timestamp":1597486886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1478951513001260\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,13]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["S1478951513001260"],"URL":"https:\/\/doi.org\/10.1017\/s1478951513001260","relation":{},"ISSN":["1478-9515","1478-9523"],"issn-type":[{"value":"1478-9515","type":"print"},{"value":"1478-9523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,13]]}}}