{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:00:13Z","timestamp":1787504413593,"version":"build-2736575974"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15ck0106059h0002"],"award-info":[{"award-number":["15ck0106059h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1478951521001565_sec_a1\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>There is no widely used prognostic model for delirium in patients with advanced cancer. The present study aimed to develop a decision tree prediction model for a short-term outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951521001565_sec_a2\" sec-type=\"methods\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This is a secondary analysis of a multicenter and prospective observational study conducted at 9 psycho-oncology consultation services and 14 inpatient palliative care units in Japan. We used records of patients with advanced cancer receiving pharmacological interventions with a baseline Delirium Rating Scale Revised-98 (DRS-R98) severity score of \u226510. A DRS-R98 severity score of &lt;10 on day 3 was defined as the study outcome. The dataset was randomly split into the training and test dataset. A decision tree model was developed using the training dataset and potential predictors. The area under the curve (AUC) of the receiver operating characteristic curve was measured both in 5-fold cross-validation and in the independent test dataset. Finally, the model was visualized using the whole dataset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951521001565_sec_a3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Altogether, 668 records were included, of which 141 had a DRS-R98 severity score of &lt;10 on day 3. The model achieved an average AUC of 0.698 in 5-fold cross-validation and 0.718 (95% confidence interval, 0.627\u20130.810) in the test dataset. The baseline DRS-R98 severity score (cutoff of 15), hypoxia, and dehydration were the important predictors, in this order.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951521001565_sec_a4\">\n                    <jats:title>Significance of results<\/jats:title>\n                    <jats:p>We developed an easy-to-use prediction model for the short-term outcome of delirium in patients with advanced cancer receiving pharmacological interventions. The baseline severity of delirium and precipitating factors of delirium were important for prediction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1478951521001565","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T10:48:01Z","timestamp":1632998881000},"page":"153-158","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":14,"title":["A decision tree prediction model for a short-term outcome of delirium in patients with advanced cancer receiving pharmacological interventions: A secondary analysis of a multicenter and prospective observational study (Phase-R)"],"prefix":"10.1017","volume":"20","author":[{"given":"Ken","family":"Kurisu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Inada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isseki","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asao","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Iwase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Akechi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Oyamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuhiro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Kaneishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Sumitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8164-4910","authenticated-orcid":false,"given":"Kazuhiro","family":"Yoshiuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"S1478951521001565_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.12.108"},{"key":"S1478951521001565_ref32","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018-0242"},{"key":"S1478951521001565_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2669"},{"key":"S1478951521001565_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00360-8"},{"key":"S1478951521001565_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.07.004"},{"key":"S1478951521001565_ref41","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1013"},{"key":"S1478951521001565_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2010.05.006"},{"key":"S1478951521001565_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy147"},{"key":"S1478951521001565_ref30","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.12067"},{"key":"S1478951521001565_ref14","first-page":"425","article-title":"Japanese 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