{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:31:31Z","timestamp":1776493891913,"version":"3.51.2"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1478951522001808_sec1a\"><jats:title>Background<\/jats:title><jats:p>Despite increasing reports of thiamine deficiency (TD) among cancer patients, there remain some patients with borderline thiamine concentrations (BTC). However, it is unclear whether such patients subsequently develop TD.<\/jats:p><\/jats:sec><jats:sec id=\"S1478951522001808_sec2b\"><jats:title>Methods<\/jats:title><jats:p>Here, we report cases of cancer patients progressing to TD within a short time period after presentation with BTC (24\u201328 ng\/ml).<\/jats:p><\/jats:sec><jats:sec id=\"S1478951522001808_sec3c\"><jats:title>Results<\/jats:title><\/jats:sec><jats:sec id=\"S1478951522001808_sec4d\"><jats:title>Case 1<\/jats:title><jats:p>A 49-year-old female with lung cancer. During treatment for depression, the patient showed a decreased appetite, and a blood sample revealed BTC (25 ng\/ml). Fourteen days later, she reported a continued loss of appetite, and despite the absence of the 3 classical signs of Wernicke encephalopathy (WE), additional testing showed a thiamine level of 23 ng\/ml, leading to a diagnosis of TD.<\/jats:p><\/jats:sec><jats:sec id=\"S1478951522001808_sec5e\"><jats:title>Case 2<\/jats:title><jats:p>A 65-year-old female developed depression during chemotherapy for angiosarcoma. Her blood sample revealed BTC (25 ng\/ml). Seven days later, despite the absence of the classical signs of WE, a further testing revealed a thiamine level of 20 ng\/ml.<\/jats:p><\/jats:sec><jats:sec id=\"S1478951522001808_sec6f\"><jats:title>Case 3<\/jats:title><jats:p>A 41-year-old female developed depression during chemotherapy for ovarian cancer. No loss of appetite was observed, but a blood sample revealed BTC (25 ng\/ml). Seven days later, despite the absence of the classical signs of WE or decreased appetite, further testing revealed a thiamine level of 19 ng\/ml.<\/jats:p><\/jats:sec><jats:sec id=\"S1478951522001808_sec7g\"><jats:title>Significance of results<\/jats:title><jats:p>Depressed cancer patients with BTC may develop TD within a short time frame. To prevent TD, health-care professionals should maintain an awareness of its potential and the need for regular testing of thiamine level or prophylactic replacement therapy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1478951522001808","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T07:24:12Z","timestamp":1674458652000},"page":"768-771","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Can depressed cancer patients with a borderline thiamine concentration develop deficiency within a short time period?"],"prefix":"10.1017","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2357-9823","authenticated-orcid":false,"given":"Nozomu","family":"Uchida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-1284","authenticated-orcid":false,"given":"Mayumi","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Onizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryota","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Mizunuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2949-2734","authenticated-orcid":false,"given":"Hideki","family":"Onishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"S1478951522001808_ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000237825"},{"key":"S1478951522001808_ref9","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951521000900"},{"key":"S1478951522001808_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2012.04.008"},{"key":"S1478951522001808_ref18","article-title":"Thiamine 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