{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T01:10:03Z","timestamp":1743988203839,"version":"3.40.3"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1478951523001347_sec1a\"><jats:title>Objectives<\/jats:title><jats:p>To describe levels of pain over time during disease progression in individual patients and for a total sample of patients with motor neuron disease (MND), respectively, and to examine associations between pain, disease severity, health-related quality of life (HRQOL), and depression.<\/jats:p><\/jats:sec><jats:sec id=\"S1478951523001347_sec2b\"><jats:title>Methods<\/jats:title><jats:p>A prospective cohort study was conducted on 68 patients with MND, including data collected on five occasions over a period of 2 years. Pain was assessed using the Brief Pain Inventory \u2013 Short Form. Depression was assessed using the Amyotrophic Lateral Sclerosis (ALS)-Depression-Inventory (ADI-12). Disability progression was measured using the Amyotrophic Lateral Sclerosis Functional Rating Scale \u2013 Revised Version (ALSFRS-R). HRQOL was assessed using the Amyotrophic Lateral Sclerosis Assessment Questionnaire (ALSAQ-5).<\/jats:p><\/jats:sec><jats:sec id=\"S1478951523001347_sec3c\"><jats:title>Results<\/jats:title><jats:p>Participants reported great individual variation over time. The median level of pain was 4 (min 0 and max 10). Higher levels of pain during the last 24\u00a0h were associated with higher depression scores (ADI-12), poorer quality of life (ALSAQ-5), and lower reporting of fine and gross motor skills (ALSFRS-R). Baseline pain levels did not predict future values of depression and function. Individuals reporting average pain &gt;3 experienced more hopelessness toward the future and reported higher depression scores compared with participants reporting average pain &lt;3.<\/jats:p><\/jats:sec><jats:sec id=\"S1478951523001347_sec4d\"><jats:title>Significance of results<\/jats:title><jats:p>Great within-individual variation of pain intensity was reported. Pain intensity was associated with depression, function and HRQOL cross-sectionally, but it did not have a strong prognostic value for future depression, function, or HRQOL. Patients with MND should be offered frequent assessment of pain and depressive symptoms in person-centered care, allowing for individualization of treatment.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1478951523001347","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T09:23:11Z","timestamp":1699867391000},"page":"1150-1157","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Pain in patients with motor neuron disease: Variation of pain and association with disease severity, health-related quality of life and depression \u2013 A longitudinal study"],"prefix":"10.1017","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5803-296X","authenticated-orcid":false,"given":"S\u00f6ren","family":"Sp\u00f6rndly-Nees","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta","family":"Jakobsson 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