{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T22:32:33Z","timestamp":1777761153288,"version":"3.51.4"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1478951524001536_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Patients with advanced cancer present various symptoms as their disease progresses. Among these, fatigue is a frequent symptom in patients with advanced cancer and is associated with decreased quality of life (QOL). However, there are few reports regarding its association with thiamine deficiency (TD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951524001536_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report a case in which we found TD in a patient with advanced lung cancer who presented with weight loss, significant fatigue, and appeared to have a worsening general condition, for whom symptoms were dramatically improved within a short period of time by intravenous administration of thiamine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951524001536_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient was a 76-year-old woman who had been diagnosed with lung cancer and liver metastases 6 months earlier. Due to interstitial pneumonia, she was not a candidate for chemotherapy and so palliative care was started. At 8 months after initial diagnosis, the patient complained of fatigue during a medical examination, so a blood sample was taken. A week later, she visited the hospital with a cane. She felt extremely fatigued and was unable to stand, but results from the previous blood test revealed that a TD. The fatigue disappeared 15 minutes after intravenous administration of thiamine and she was able to return home without the cane.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951524001536_sec4d\">\n                    <jats:title>Significance of results<\/jats:title>\n                    <jats:p>Fatigue is a frequent symptom in advanced cancer patients, and TD may be the underlying cause. Inclusion of TD in the differential diagnosis may contribute to improving patient QOL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1478951524001536","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T05:21:47Z","timestamp":1727932907000},"page":"2122-2124","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Thiamine deficiency as a differential diagnosis for severe fatigue in terminally ill cancer patients"],"prefix":"10.1017","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2949-2734","authenticated-orcid":false,"given":"Hideki","family":"Onishi","sequence":"first","affiliation":[{"name":"Saitama Medical University International Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Sato","sequence":"additional","affiliation":[{"name":"Morigaoka Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Uchida","sequence":"additional","affiliation":[{"name":"Saitama Medical University International Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Mitsubishi Kyoto Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izumi","family":"Sato","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Sciences, Nagasaki University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Onizawa","sequence":"additional","affiliation":[{"name":"Anz clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Ito Internal Medicine and Pediatric Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-1284","authenticated-orcid":false,"given":"Mayumi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Saitama Medical University International Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"S1478951524001536_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-021-00859-9"},{"key":"S1478951524001536_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951522001808"},{"key":"S1478951524001536_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/pon.4155"},{"key":"S1478951524001536_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/jgf2.523"},{"key":"S1478951524001536_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2007.02.007"},{"key":"S1478951524001536_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/0269216307085183"},{"key":"S1478951524001536_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951517000992"},{"key":"S1478951524001536_ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28462-2"},{"key":"S1478951524001536_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.4.341"},{"key":"S1478951524001536_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuv107"},{"key":"S1478951524001536_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03153.x"},{"key":"S1478951524001536_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70104-7"},{"key":"S1478951524001536_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050281"}],"container-title":["Palliative and Supportive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1478951524001536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:09:42Z","timestamp":1777471782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1478951524001536\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S1478951524001536"],"URL":"https:\/\/doi.org\/10.1017\/s1478951524001536","relation":{},"ISSN":["1478-9515","1478-9523"],"issn-type":[{"value":"1478-9515","type":"print"},{"value":"1478-9523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}