{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:34:50Z","timestamp":1791963290102,"version":"4.3.4"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"unspecified","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1478951524001998_sec1a\">\n\t    <jats:title>Objectives<\/jats:title>\n\t    <jats:p>Caring for children with solid tumors (STs) can impact caregiver\u2019s physical and mental health. Caregiver mastery, which influences psychological well-being, is vital in improving outcomes for both caregivers and children. The study aimed to investigate the relationship between caregiver mastery, anxiety, depression, fear of disease progression (FoP), caregiver burden, and the quality of life (QOL) of children with ST.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1478951524001998_sec2b\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>This cross-sectional study was conducted from June 2022 to April 2023 at a Grade A tertiary hospital in Shandong. Family caregivers of children with ST completed several validated measures, including the Pediatric Quality of Life Inventory (PedsQL) 3.0 Cancer Module, the Fear of Progression Questionnaire-parent version (FoP-Q-SF\/PR), the Zarit Burden Interview Scale (ZBI), the hospital anxiety and depression scale (HADS), and the Caregiver Mastery Scale. Multiple linear regression analyses assessed the relationships between FoP, caregiver burden, anxiety, depression, caregiver mastery, and children\u2019s QOL. Results were expressed as <jats:italic>\u03b2<\/jats:italic> and 95% confidence intervals (CIs).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1478951524001998_sec3c\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>A total of 454 caregivers participated. Caregiver mastery was positively correlated with children\u2019s QOL (<jats:italic>\u03b2<\/jats:italic> = 0.80, 95% CI: 0.20 to 1.39). Depression (<jats:italic>\u03b2<\/jats:italic> = \u22120.64, 95% CI: \u22120.83 to \u22120.45), anxiety (<jats:italic>\u03b2<\/jats:italic> = \u22120.67, 95% CI: \u22120.85 to \u22120.49), caregiver burden (<jats:italic>\u03b2<\/jats:italic> = \u22121.20, 95% CI: \u22121.60 to \u22120.80), and FoP (<jats:italic>\u03b2<\/jats:italic> = \u22120.04, 95% CI: \u22120.05 to \u22120.03) were negatively related to children\u2019s QOL. Caregiver mastery moderated the associations between depression, caregiver burden, FoP, and children\u2019s QOL, while also improving the effect of mild anxiety on QOL.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1478951524001998_sec4d\">\n\t    <jats:title>Significance of results<\/jats:title>\n\t    <jats:p>The study underscores the importance of fostering caregiver mastery to mitigate the negative impact of caregiver distress on children\u2019s QOL and improve outcomes for both caregivers and children with solid tumors.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1478951524001998_sec5e\">\n\t    <jats:title>Conclusion<\/jats:title>\n\t    <jats:p>Caregiver mastery moderates the effects of anxiety, depression, FoP, and caregiver burdenon children\u2019s QOL. Supporting caregiver mastery can alleviate caregiver burden and enhance both caregiver and child well-being.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s1478951524001998","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T07:43:21Z","timestamp":1737445401000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["The effect of caregiver mastery on the associations of depression, anxiety, caregiver burden, fear of disease progression with quality of life among children with solid tumors"],"prefix":"10.1017","volume":"23","author":[{"given":"Fangfang","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4219-4461","authenticated-orcid":false,"given":"Yingtao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"S1478951524001998_ref17","article-title":"Taking 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Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e28"}}