{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:34:46Z","timestamp":1790998486950,"version":"4.1.0"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"unspecified","delay-in-days":233,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1478951525100217_sec1a\">\n\t    <jats:title>Objectives<\/jats:title>\n\t    <jats:p>Brain tumors are associated with negative changes in sense of self and increased distress early in the illness trajectory. Dignity Therapy (DT) is a brief 2-session therapeutic intervention for patients at end-of-life (EOL) that helps conserve a patient\u2019s sense of dignity or self. DT has shown positive results for patients at EOL including increased meaning, improved quality of life (QOL), and reduced distress, with limited research to date on patients early in their illness trajectory (non-EOL). This pre-post design pilot study investigated the benefits and feasibility of DT for 2 groups of patients with incurable brain tumors.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1478951525100217_sec2b\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>A total of 51 participants were recruited, of whom 39 participated. Participants were grouped as EOL (prognosis &lt; 1 year, <jats:italic>n<\/jats:italic> = 21) and non-EOL (prognosis &gt; 1 year, <jats:italic>n<\/jats:italic> = 18). Participants completed self-report measures to determine changes in QOL, psychosocial well-being (i.e., spiritual well-being, connection, and posttraumatic growth), and death anxiety, at baseline, 1 week, and 5 weeks post-intervention.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1478951525100217_sec3c\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>The intervention had a high completion rate, with 37 of 39 participants (95%) completing DT. Linear regression models fitted with generalized estimating equations (GEEs) showed within- and between-group significant changes in all domains for both groups, but were particularly beneficial for non-EOL participants.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1478951525100217_sec4d\">\n\t    <jats:title>Significance of results<\/jats:title>\n\t    <jats:p>This study demonstrated that DT effectively enhanced psychosocial well-being in patients with brain tumors, including reductions in death anxiety and dignity-related distress. Non-EOL participants benefited most and had higher completion rates, highlighting the intervention\u2019s feasibility and the need for further research in earlier stages of terminal illness.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s1478951525100217","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T07:30:09Z","timestamp":1755847809000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the impact of early dignity therapy on quality of life in patients with brain tumors: A pilot study"],"prefix":"10.1017","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-0957","authenticated-orcid":false,"given":"Aaron","family":"Palachi","sequence":"first","affiliation":[{"name":"Sunnybrook Health Sciences Centre"},{"name":"Toronto Metropolitan 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