{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:08:30Z","timestamp":1786738110306,"version":"build-2736575974"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"unspecified","delay-in-days":170,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S147895152510031X_sec1a\">\n\t    <jats:title>Objectives<\/jats:title>\n\t    <jats:p>Cholangiocarcinoma (CCA) is the second most lethal primary hepatic malignancy. It has been well-reported that most cancer patients prefer to die at home or in a hospice facility. However, there is limited data on the place of death for CCA patients. We evaluated trends and disparities in place of death for patients with CCA from 1999 to 2020.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S147895152510031X_sec2b\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>Using the CDC WONDER database (1999\u20132020), we calculated the frequency of CCA deaths at home\/hospice and the average annual percentage change (AAPC) over this period stratified by race, age, gender, and region. We employed logistic regression to assess for associations between these variables and place of death for patients whose death was attributed to CCA.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S147895152510031X_sec3c\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Among 140,422 deaths, a rise in deaths occurred in home\/hospice facilities compared to inpatient medical or nursing facilities across all variables examined. Blacks and individuals \u2265 85 had the highest proportion of deaths outside of home\/hospice. However, Blacks showed the highest AAPC (8.56%) in home\/hospice deaths, followed by Asians (AAPC 8.44%). In contrast, individuals aged 45\u201354 saw the lowest AAPC (4.27%). Non-whites were less likely to die at home\/hospice, with Blacks demonstrating the lowest adjusted odds ratio (aOR 0.64). Those \u2265 85 were less likely to die in home\/hospice (aOR 0.78), whereas individuals aged between 55\u201364 (aOR 1.11) and 65\u201374 (aOR 1.12) had increased odds of dying in these settings. Patients from the Western region were the most likely to die at home\/hospice (aOR 1.04).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S147895152510031X_sec4d\">\n\t    <jats:title>Significance of results<\/jats:title>\n\t    <jats:p>Our study highlights disparities in place of death of patients with CCA amongst races, regions, and ages. Non-whites, extremes of ages, and patients from the Northeast have disproportionately poor outcomes in terms of end-of-life care in the US. These findings emphasize the need for efforts to address sociodemographic disparities in end-of-life care to improve patient-centered health outcomes.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s147895152510031x","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:39:38Z","timestamp":1750397978000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Trends and disparities in place of death among patients with cholangiocarcinoma: A two-decade analysis"],"prefix":"10.1017","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-9341","authenticated-orcid":false,"given":"Imran","family":"Qureshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmi","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Rella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Botterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazan","family":"Abboud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritik","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaveh","family":"Hajifathalian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gaglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Al-Khazraji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"S147895152510031X_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djx028"},{"key":"S147895152510031X_ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.e24077"},{"key":"S147895152510031X_ref21","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.20"},{"key":"S147895152510031X_ref1","doi-asserted-by":"publisher","DOI":"10.21037\/cco-22-109"},{"key":"S147895152510031X_ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001410"},{"key":"S147895152510031X_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23335"},{"key":"S147895152510031X_ref23","doi-asserted-by":"publisher","DOI":"10.1177\/0193945903259207"},{"key":"S147895152510031X_ref24","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07175-4"},{"key":"S147895152510031X_ref14","doi-asserted-by":"publisher","DOI":"10.1089\/pmr.2020.0023"},{"key":"S147895152510031X_ref18","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20150010"},{"key":"S147895152510031X_ref28","unstructured":"Zamani, Z and Fatima, S (2023) Biliary Tract Cancer (Archived). Treasure Island (FL): StatPearls Publishing. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK560550\/"},{"key":"S147895152510031X_ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.02.038"},{"key":"S147895152510031X_ref27","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.41422"},{"key":"S147895152510031X_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14484"},{"key":"S147895152510031X_ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1472-684X-12-7"},{"key":"S147895152510031X_ref3","unstructured":"Centers For Disease Control And Prevention Ncfhs (2024) National vital statistics system, mortality 1999-2020 on cdc wonder online database, released in 2021. Available at http:\/\/wonder.cdc.gov\/ucd-icd10.html (accessed 4 May 2024)."},{"key":"S147895152510031X_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(01)00406-7"},{"key":"S147895152510031X_ref19","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph181910004"},{"key":"S147895152510031X_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31737"},{"key":"S147895152510031X_ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.217"},{"key":"S147895152510031X_ref25","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200201000-00010"},{"key":"S147895152510031X_ref26","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3863"},{"key":"S147895152510031X_ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000453013"},{"key":"S147895152510031X_ref22","doi-asserted-by":"publisher","DOI":"10.1001\/jamahealthforum.2023.4240"},{"key":"S147895152510031X_ref12","doi-asserted-by":"publisher","DOI":"10.1089\/109662102320880499"},{"key":"S147895152510031X_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16294"},{"key":"S147895152510031X_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-022-02654-x"},{"key":"S147895152510031X_ref20","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-023-13122-1"}],"container-title":["Palliative and Supportive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S147895152510031X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T05:39:39Z","timestamp":1750397979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S147895152510031X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":28,"alternative-id":["S147895152510031X"],"URL":"https:\/\/doi.org\/10.1017\/s147895152510031x","relation":{},"ISSN":["1478-9515","1478-9523"],"issn-type":[{"value":"1478-9515","type":"print"},{"value":"1478-9523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e122"}}