{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:11:30Z","timestamp":1777936290238,"version":"3.51.4"},"reference-count":6,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"unspecified","delay-in-days":233,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S1478951525100503_sec1a\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of cancer treatment, significantly affecting patients\u2019 quality of life. Current pharmacological treatments are often ineffective or poorly tolerated, necessitating alternative therapeutic approaches. Scrambler Therapy (ST), a non-invasive neuromodulation technique, has shown potential for reducing neuropathic pain, but optimal dosing regimens remain undefined.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1478951525100503_sec2b\">\n\t    <jats:title>Objective<\/jats:title>\n\t    <jats:p>This case study aims to evaluate the effectiveness of Scrambler Therapy in reducing pain levels and improving functional status in a patient with chemotherapy-induced peripheral neuropathy.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1478951525100503_sec3c\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>A single patient diagnosed with CIPN was treated with Scrambler Therapy over a series of sessions. Pain levels and functional status were measured using standardized assessment tools before, during, and after the therapy to evaluate the impact of ST on symptom relief and daily functioning.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1478951525100503_sec4d\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>After completing the Scrambler Therapy sessions, the patient reported significant reductions in pain intensity and notable improvements in functional status. These improvements were sustained several weeks and months following the therapy, indicating the potential long-term benefits of ST for managing CIPN.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S1478951525100503_sec5e\">\n\t    <jats:title>Conclusion<\/jats:title>\n\t    <jats:p>This case study demonstrates the potential of Scrambler Therapy as an effective treatment option for reducing pain and improving functional status in patients with chemotherapy-induced peripheral neuropathy. These findings suggest that ST may provide a promising non-invasive alternative to current treatments for managing neuropathic pain in cancer patients.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s1478951525100503","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T07:30:04Z","timestamp":1755847804000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Scrambler therapy for chemotherapy-induced peripheral neuropathy: A case report"],"prefix":"10.1017","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5122-7799","authenticated-orcid":false,"given":"Zhu","family":"Wang","sequence":"first","affiliation":[{"name":"The Johns Hopkins Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Carducci","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Marineo","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Smith","sequence":"additional","affiliation":[{"name":"The Johns Hopkins Hospital"},{"name":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"S1478951525100503_ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2110098"},{"key":"S1478951525100503_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.13355"},{"key":"S1478951525100503_ref2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.0914"},{"key":"S1478951525100503_ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01399"},{"key":"S1478951525100503_ref5","doi-asserted-by":"publisher","DOI":"10.1177\/0825859719827589"},{"key":"S1478951525100503_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-051073"}],"container-title":["Palliative and Supportive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1478951525100503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T07:30:04Z","timestamp":1755847804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1478951525100503\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":6,"alternative-id":["S1478951525100503"],"URL":"https:\/\/doi.org\/10.1017\/s1478951525100503","relation":{},"ISSN":["1478-9515","1478-9523"],"issn-type":[{"value":"1478-9515","type":"print"},{"value":"1478-9523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e149"}}