{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:47:51Z","timestamp":1781552871606,"version":"3.54.5"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"unspecified","delay-in-days":295,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1478951525100941_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Psychospiritual distress affects many patients with cancer, contributing to diminished quality of life, decreased survival and a desire for hastened death. The current standard of care, which primarily consists of antidepressants and psychotherapy, has demonstrated only modest benefits. Psilocybin-assisted therapy (PAT) has shown evidence of rapid, durable, and significant effects on measures of both depression and anxiety in this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951525100941_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 51-year-old man diagnosed with metastatic lung cancer, referred to palliative care (PC) with a prognosis of less than 6 months, experienced depression and anxiety in the context of demoralization and existential distress. His suffering persisted despite psychotherapy and treatment with 100 mg of sertraline. He was granted access to PAT through Health Canada\u2019s Special Access Program (SAP) and was treated with 25 mg of oral psilocybin in a homecare setting, with preparative and integrative therapy prior to and following the PAT session.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951525100941_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PAT was well tolerated, with significant decreases in both anxiety and depression. The patient subjectively reported a sustained reduction in suffering and improved well-being at 2 months post-intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951525100941_sec4d\">\n                    <jats:title>Significance of results<\/jats:title>\n                    <jats:p>PAT, when utilized within an appropriate therapeutic framework, may be safely delivered at home and may serve as an effective and long-lasting treatment for symptoms of anxiety and depression associated with psychospiritual symptoms of existential distress in PC. Future studies should examine differences in outcomes between clinical and homecare settings for PAT, and could include creating practice guidelines and protocols for home-based PAT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1478951525100941","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T09:09:45Z","timestamp":1761210585000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Home-based psilocybin-assisted therapy for a patient with advanced cancer: A case report"],"prefix":"10.1017","volume":"23","author":[{"given":"Houman","family":"Farzin","sequence":"first","affiliation":[{"name":"Jewish General Hospital"},{"name":"McGill University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6515-3176","authenticated-orcid":false,"given":"Benjamin","family":"Koren","sequence":"additional","affiliation":[{"name":"University of Vermont Larner College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e9na","family":"Ferrier","sequence":"additional","affiliation":[{"name":"Home Care Hospital Soins et Sant\u00e9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8928-4051","authenticated-orcid":false,"given":"Justin J.","family":"Sanders","sequence":"additional","affiliation":[{"name":"McGill University"},{"name":"McGill University Health Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Garel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Montr\u00e9al"},{"name":"Stanford University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"S1478951525100941_ref23","first-page":"68","article-title":"The symptomatic treatment of incurable malignant disease","volume":"4","author":"Saunders","year":"1964","journal-title":"The Prescriber\u2019s Journal"},{"key":"S1478951525100941_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-06027-y"},{"key":"S1478951525100941_ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12206563"},{"key":"S1478951525100941_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2025.1457"},{"key":"S1478951525100941_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-66817-0"},{"key":"S1478951525100941_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/2050324516683325"},{"key":"S1478951525100941_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03685-9"},{"key":"S1478951525100941_ref16","doi-asserted-by":"publisher","DOI":"10.1177\/0022167817711304"},{"key":"S1478951525100941_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.35010"},{"key":"S1478951525100941_ref29","doi-asserted-by":"publisher","DOI":"10.1126\/science.adf0435"},{"key":"S1478951525100941_ref4","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2017.0684"},{"key":"S1478951525100941_ref12","unstructured":"Health Canada. Notice to stakeholders: Requests to the Special Access Program (SAP) involving psychedelic-assisted psychotherapy . [Online] Available at: https:\/\/www.canada.ca\/en\/health-canada\/services\/drugs-health-products\/drug-products\/announcements\/requests-special-access-program-psychedelic-assisted-psychotherapy.html [Accessed 18 Apr. 2023]."},{"key":"S1478951525100941_ref25","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675764"},{"key":"S1478951525100941_ref30","first-page":"CD011006","article-title":"Antidepressants for the treatment of depression in people with cancer","volume":"3","author":"Vita","year":"2023","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S1478951525100941_ref28","doi-asserted-by":"publisher","DOI":"10.1037\/t06496-000"},{"key":"S1478951525100941_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675513"},{"key":"S1478951525100941_ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00974"},{"key":"S1478951525100941_ref7","doi-asserted-by":"publisher","DOI":"10.26443\/ijwpc.v10i1.373"},{"key":"S1478951525100941_ref5","doi-asserted-by":"publisher","DOI":"10.1177\/0269881118754710"},{"key":"S1478951525100941_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2025.05.018"},{"key":"S1478951525100941_ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.1040217"},{"key":"S1478951525100941_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/0269881115609019"},{"key":"S1478951525100941_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2023.03.007"},{"key":"S1478951525100941_ref21","first-page":"125","article-title":"A review of Acceptance and Commitment Therapy (ACT) empirical evidence: correlational, experimental psychopathology, component and outcome studies","volume":"10","author":"Ruiz","year":"2010","journal-title":"International Journal of Psychology and Psychological Therapy"},{"key":"S1478951525100941_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.11.046"},{"key":"S1478951525100941_ref27","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20556"},{"key":"S1478951525100941_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s11469-024-01253-9"},{"key":"S1478951525100941_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5586"},{"key":"S1478951525100941_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-4866-2_17"},{"key":"S1478951525100941_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881119897615"},{"key":"S1478951525100941_ref13","doi-asserted-by":"publisher","DOI":"10.2307\/3528690"}],"container-title":["Palliative and Supportive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1478951525100941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T09:09:47Z","timestamp":1761210587000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1478951525100941\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":31,"alternative-id":["S1478951525100941"],"URL":"https:\/\/doi.org\/10.1017\/s1478951525100941","relation":{},"ISSN":["1478-9515","1478-9523"],"issn-type":[{"value":"1478-9515","type":"print"},{"value":"1478-9523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e189"}}