{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:06:53Z","timestamp":1784675213909,"version":"3.55.0"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"unspecified","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1478951526101709_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Randomized controlled trials (RCTs) of the Collaborative Care Model demonstrate strong evidence for effectively managing depression in a stepped-care approach across diverse patient populations. Despite alignment with the American Society of Clinical Oncology guidelines, which recommend a stepped-care approach for managing depression and anxiety in cancer patients, implementation of collaborative care in cancer centers remains limited and sparse real-world data exist. The Supportive Oncology Collaborative, a program integrating behavioral health and palliative care, was developed at an NCI-designated academic cancer center. This study aims to evaluate depression outcomes within this collaborative care program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526101709_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on patients with at least 2 Patient Health Questionnaire-9 (PHQ-9) scores recorded within a 12-month period between January 2022 and December 2023 at 1 regional campus. Depression response, defined as a 50% reduction in PHQ-9 scores, was assessed at 12 and 24 weeks. Response rates were compared to those reported in RCTs of collaborative care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526101709_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean PHQ-9 scores were 17.3 at baseline (\n                      <jats:italic>n<\/jats:italic>\n                      = 47), 11.1 at 12 weeks (\n                      <jats:italic>n<\/jats:italic>\n                      = 43), and 10.1 at 24 weeks (\n                      <jats:italic>n<\/jats:italic>\n                      = 22). Depression response rates were 34.9% at 12 weeks (\n                      <jats:italic>n<\/jats:italic>\n                      = 43) and 54.5% at 24 weeks (\n                      <jats:italic>n<\/jats:italic>\n                      = 22).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526101709_sec4d\">\n                    <jats:title>Significance of results<\/jats:title>\n                    <jats:p>We observed depression response rates comparable to those reported in RCTs of collaborative care in individuals with cancer. However, the high proportion of missing data highlights the difficulty of tracking outcomes in real-world clinical settings and the need for further evaluation and strategies to improve data completeness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1478951526101709","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:31:28Z","timestamp":1770892288000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Impact of a collaborative care program on depression outcomes: A real-world retrospective analysis"],"prefix":"10.1017","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-9228","authenticated-orcid":false,"given":"Carrie C.","family":"Wu","sequence":"first","affiliation":[{"name":"Dana-Farber Cancer Institute"},{"name":"Harvard Medical School"},{"name":"Brigham and Women\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Ketron","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute"},{"name":"Harvard Medical School"},{"name":"Brigham and Women\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Pirl","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Lally","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute"},{"name":"Harvard Medical School"},{"name":"Brigham and Women\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Cubbison","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute"},{"name":"Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miryam","family":"Yusufov","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute"},{"name":"Harvard Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"S1478951526101709_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2012.01.019"},{"key":"S1478951526101709_ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0728-6"},{"key":"S1478951526101709_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5488"},{"key":"S1478951526101709_ref1","first-page":"Cd006525","article-title":"Collaborative care for depression and anxiety problems","volume":"10","author":"Archer","year":"2012","journal-title":"Cochrane Database of Systematic 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Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use and\/or adaptation of the article.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e57"}}