{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:13:31Z","timestamp":1793218411932,"version":"4.5.0"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"unspecified","delay-in-days":35,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1478951526101758_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hepatocellular carcinoma (HCC) is associated with high mortality and imposes substantial symptom and psychological burdens; however, the impact of different treatment modalities on quality of life (QoL) and mental health remains underexplored. This study aimed to examine the associations among symptom distress, depression, and QoL across various HCC treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526101758_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional study was conducted with 101 inpatients at a regional hospital in Taiwan (October 2020\u2013December 2021). Patients received hepatic resection (HR), radiofrequency ablation (RFA), transarterial chemoembolization (TACE), hepatic arterial infusion chemotherapy (HAIC), or immunotherapy (IT). Data were collected using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30), the Hospital Anxiety and Depression Scale (HADS), and the Brief Symptom Rating Scale (BSRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526101758_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      RFA patients reported better functional scores (96.13 \u00b1 7.55) and lower HADS scores (18.31\u00a0\u00b1\u00a04.92) than those treated with TACE, HAIC, or IT (function: 87.77\u00a0\u00b1\u00a017.77; HADS: 23.26\u00a0\u00b1\u00a07.66). These differences may reflect earlier disease stage and better baseline health in RFA recipients. Older age and advanced stage were associated with poorer global health (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), while female gender (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u2212\u00a07.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.014) and disease recurrence (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u2212\u00a06.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.019) were associated with lower functional status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526101758_sec4d\">\n                    <jats:title>Significance of results<\/jats:title>\n                    <jats:p>Treatment type, disease stage, and demographics significantly shape QoL and mental health in HCC patients. Minimally invasive therapies like RFA may preserve QoL in early-stage disease, while invasive or palliative treatments necessitate greater psychosocial support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1478951526101758","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:51:24Z","timestamp":1770288684000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Treatment-related differences in quality of life and psychological distress among patients with hepatocellular carcinoma: A cross-sectional analysis"],"prefix":"10.1017","volume":"24","author":[{"given":"Yi-Tseng","family":"Tsai","sequence":"first","affiliation":[{"name":"China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zan-Ting","family":"Lu","sequence":"additional","affiliation":[{"name":"An Nan Hospital, China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Yu","family":"Kuo","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Han","family":"Yang","sequence":"additional","affiliation":[{"name":"An Nan Hospital, China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jing","family":"Tsai","sequence":"additional","affiliation":[{"name":"Chang Gung University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun Feng","family":"Tsai","sequence":"additional","affiliation":[{"name":"An Nan Hospital, China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-6363","authenticated-orcid":false,"given":"Wen-Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"National Tainan Junior College of Nursing"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"S1478951526101758_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30207-1"},{"key":"S1478951526101758_ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915745"},{"key":"S1478951526101758_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00634747"},{"key":"S1478951526101758_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70285-7"},{"key":"S1478951526101758_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.08.045"},{"key":"S1478951526101758_ref3","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA: CA Cancer Journal for Clinicians"},{"key":"S1478951526101758_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.08.025"},{"key":"S1478951526101758_ref24","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200007000-00003"},{"key":"S1478951526101758_ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.662777"},{"key":"S1478951526101758_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-021-02789-2"},{"key":"S1478951526101758_ref16","first-page":"687","article-title":"Development and verification of validity and reliability of a short screening instrument to identify psychiatric morbidity","volume":"102","author":"Lee","year":"2003","journal-title":"Journal of the Formosan Medical Association"},{"key":"S1478951526101758_ref19","article-title":"Alcohol use disorder and depressive disorders","volume":"40","author":"McHugh","year":"2019","journal-title":"Alcohol Res"},{"key":"S1478951526101758_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31288"},{"key":"S1478951526101758_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.03.008"},{"key":"S1478951526101758_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15169"},{"key":"S1478951526101758_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-008-9365-y"},{"key":"S1478951526101758_ref23","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0136"},{"key":"S1478951526101758_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08649-X"},{"key":"S1478951526101758_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnur.2021.07.010"},{"key":"S1478951526101758_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00448-8"},{"key":"S1478951526101758_ref20","article-title":"Sorafenib in advanced hepatocellular carcinoma","volume":"359","author":"Palmer","year":"2008","journal-title":"New England Journal of Medicine"},{"key":"S1478951526101758_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-05244-8"},{"key":"S1478951526101758_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"S1478951526101758_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.8.807"}],"container-title":["Palliative and Supportive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1478951526101758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:51:25Z","timestamp":1770288685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1478951526101758\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":24,"alternative-id":["S1478951526101758"],"URL":"https:\/\/doi.org\/10.1017\/s1478951526101758","relation":{},"ISSN":["1478-9515","1478-9523"],"issn-type":[{"value":"1478-9515","type":"print"},{"value":"1478-9523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e53"}}