{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:37:02Z","timestamp":1783449422862,"version":"3.55.0"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"unspecified","delay-in-days":126,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S147895152610248X_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Older adults with cancer frequently experience high symptom burden, psychological distress, and reduced quality of life. Integrating palliative nursing interventions into routine oncology care has the potential to improve these outcomes, yet evidence examining their measurable effects remains limited. This study aimed to examine the effects of integrated palliative nursing interventions on quality of life, psychological outcomes, and symptom burden among older adults with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S147895152610248X_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A quasi-experimental one-group pre-test\u2013post-test design was conducted at King Khaled Hospital, Al-Kharj, Saudi Arabia, including 80 older adults (\u226560\u00a0years) with confirmed cancer diagnosis. Participants received a structured 6-week integrated palliative nursing intervention comprising 12 sessions (2 sessions\/week) addressing physical, psychological, social, functional, and spiritual needs. Outcome measures included the Functional Assessment of Cancer Therapy-General (FACT-G) for quality of life, the National Comprehensive Cancer Network (NCCN) Distress Thermometer for psychological outcomes, and the Edmonton Symptom Assessment System (ESAS-r) for symptom burden. Pre- and post-intervention assessments were conducted, and data were analyzed using paired\n                      <jats:italic>t<\/jats:italic>\n                      -tests, Pearson correlations, and multiple linear regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S147895152610248X_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All 80 participants completed the study, and no attrition was observed during the 6-week intervention period. Post-intervention, participants demonstrated significant improvements in overall quality of life (FACT-G total: 39.65\u00a0\u00b1\u00a05.51 \u2192 66.41\u00a0\u00b1\u00a06.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and all subscales. Distress scores (NCCN) decreased from 21.93\u00a0\u00b1\u00a02.49 to 6.99\u00a0\u00b1\u00a02.37 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), and total symptom burden (ESAS) declined from 63.56\u00a0\u00b1\u00a06.31 to 41.09\u00a0\u00b1\u00a06.88 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Regression analysis identified baseline scores as significant predictors of post-intervention outcomes: pre-intervention FACT-G scores and cancer type for quality of life [\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.660,\n                      <jats:italic>F<\/jats:italic>\n                      (8, 71)\u00a0=\u00a017.199,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), pre-intervention NCCN scores for distress (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.219, F (8, 71)\u00a0=\u00a02.487,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.019), and pre-intervention ESAS scores for symptom burden (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.757,\n                      <jats:italic>F<\/jats:italic>\n                      (8, 71)\u00a0=\u00a027.697,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). These results indicated that baseline status strongly predicts post-intervention outcomes, while demographic and clinical variables had minimal impact.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S147895152610248X_sec4d\">\n                    <jats:title>Significance of the results<\/jats:title>\n                    <jats:p>Structured integrated palliative nursing interventions significantly enhance quality of life and reduce psychological distress and symptom burden in older adults with cancer. Incorporating multidimensional, patient-centered palliative care within routine oncology practice can improve clinical outcomes, with baseline status serving as an important determinant of intervention effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s147895152610248x","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:48:33Z","timestamp":1778147313000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Integrated palliative nursing interventions for older adults with cancer: Effects on quality of life, psychological outcomes, and symptom burden"],"prefix":"10.1017","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8192-0017","authenticated-orcid":false,"given":"Ateya Megahed","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Prince Sattam Bin Abdulaziz University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5689-7758","authenticated-orcid":false,"given":"Donia Elsaid Fathi","family":"Zaghamir","sequence":"additional","affiliation":[{"name":"Prince Sattam Bin Abdulaziz University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"S147895152610248X_ref15","first-page":"89","article-title":"Models of integration of oncology and palliative care","volume":"4","author":"Hui","year":"2017","journal-title":"Annals of Palliative Medicine"},{"key":"S147895152610248X_ref23","first-page":"167","volume-title":"Understanding Pancreatic Cancer","author":"Mabonga","year":"2026"},{"key":"S147895152610248X_ref32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000678"},{"key":"S147895152610248X_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2025.105858"},{"key":"S147895152610248X_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-13279-7.00068-7"},{"key":"S147895152610248X_ref34","doi-asserted-by":"publisher","DOI":"10.3747\/co.19.882"},{"key":"S147895152610248X_ref21","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK-26-516010"},{"key":"S147895152610248X_ref25","volume-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae): Distress Management (Version 1.2016)","year":"2016"},{"key":"S147895152610248X_ref28","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v15.i12.113462"},{"key":"S147895152610248X_ref8","doi-asserted-by":"publisher","DOI":"10.4018\/979-8-3693-6730-8.ch006"},{"key":"S147895152610248X_ref33","article-title":"Dying with Dignity","author":"Turan","year":"2026","journal-title":"Through Nurses\u2019 Eyes: Experiences and Ethical Meanings in Palliative Care"},{"key":"S147895152610248X_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2026.103110"},{"key":"S147895152610248X_ref1","unstructured":"Aghahosseini, SS , Karami, M , Rassouli, M , et al. (2025) Impact of palliative care on the quality of life and patient satisfaction in cancer patients: A before-and-after quasi-experimental study."},{"key":"S147895152610248X_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951523002067"},{"key":"S147895152610248X_ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12912-024-02028-2"},{"key":"S147895152610248X_ref13","article-title":"Early palliative care for adults with advanced cancer","volume":"6","author":"Haun","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S147895152610248X_ref19","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0023"},{"key":"S147895152610248X_ref6","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.309"},{"key":"S147895152610248X_ref20","doi-asserted-by":"publisher","DOI":"10.4103\/ejcrp.eJCRP-D-25-00017"},{"key":"S147895152610248X_ref36","doi-asserted-by":"publisher","DOI":"10.2196\/69936"},{"key":"S147895152610248X_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/10499091241297924"},{"key":"S147895152610248X_ref11","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32080433"},{"key":"S147895152610248X_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/082585979100700202"},{"key":"S147895152610248X_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62416-2"},{"key":"S147895152610248X_ref18","doi-asserted-by":"publisher","DOI":"10.1017\/S1478951524001822"},{"key":"S147895152610248X_ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.3.570"},{"key":"S147895152610248X_ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-025-01737-y"},{"key":"S147895152610248X_ref9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.1474"},{"key":"S147895152610248X_ref27","doi-asserted-by":"publisher","DOI":"10.3390\/onco6010007"},{"key":"S147895152610248X_ref37","first-page":"1","volume-title":"The Palgrave Encyclopedia of Disability","author":"Yadav","year":"2025"},{"key":"S147895152610248X_ref29","first-page":"43","article-title":"Integrating palliative nursing interventions in oncology care: Impact on patient wellbeing","volume":"3","author":"Shaheen","year":"2025","journal-title":"Life Sciences Perspectives"},{"key":"S147895152610248X_ref31","doi-asserted-by":"publisher","DOI":"10.33024\/minh.v8i12.2227"},{"key":"S147895152610248X_ref26","first-page":"259","volume-title":"Cancer: An Integrative Approach: Principles and Strategies-from Precision Targeting to Process Oncology","author":"Paul","year":"2026"},{"key":"S147895152610248X_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnsa.2025.100343"},{"key":"S147895152610248X_ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-8"},{"key":"S147895152610248X_ref2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13222935"},{"key":"S147895152610248X_ref35","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-025-01800-8"},{"key":"S147895152610248X_ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0321586"}],"container-title":["Palliative and Supportive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S147895152610248X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:48:36Z","timestamp":1778147316000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S147895152610248X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":38,"alternative-id":["S147895152610248X"],"URL":"https:\/\/doi.org\/10.1017\/s147895152610248x","relation":{},"ISSN":["1478-9515","1478-9523"],"issn-type":[{"value":"1478-9515","type":"print"},{"value":"1478-9523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press.","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"e134"}}