{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:17:46Z","timestamp":1792671466958,"version":"4.5.0"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"unspecified","delay-in-days":133,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Pall Supp Care"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1478951526102673_sec1a\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study investigates differing aspects of wishes to hasten death (WTHD) distinguished by the extent to which WTHD were linked to patients\u2019 agency: desire for hastened death (DHD), defined as general wishes for death to come sooner, and hastening death intentions (HDI), defined as thoughts about ending one\u2019s life. In particular, this study aims to examine the differences between DHD and HDI in patients with amyotrophic lateral sclerosis (pALS) and identify predictive factors for both.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526102673_sec2b\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross-sectional nested study was conducted within a multi-center longitudinal study involving pALS from 5 European countries. Data collected included DHD (Schedule of Attitudes toward Hastened Death), HDI (\u201ccould you currently imagine ending your life?\u201d), sociodemographic and clinical characteristics, psychological distress, quality of life, and social and spiritual-existential aspects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526102673_sec3c\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In our sample of 121 pALS, 12.4% (15\/121) expressed DHD, and 28.1% (34\/121) expressed HDI. Of the 38 patients reporting any WTHD, only 11 experienced both DHD and HDI simultaneously. 23 patients reported HDI without DHD, while 4 patients expressed DHD without HDI. Multivariable logistic regression identified loneliness (OR\u00a0=\u00a01.33, 95% CI 1.03\u20131.71,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.028) and reduced meaning in life (OR\u00a0=\u00a00.89, 95% CI 0.84\u20130.95,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) as independent predictors of DHD. For HDI, independent predictors were female gender (OR\u00a0=\u00a03.31, 95% CI 1.37\u20137.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008) and lower spirituality (OR\u00a0=\u00a00.92, 95% CI 0.88\u20130.95,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1478951526102673_sec4d\">\n                    <jats:title>Significance of results<\/jats:title>\n                    <jats:p>One in 3 pALS expressed WTHD. Our separate analysis of DHD and HDI supports the existence of distinct manifestations of WTHD and varying underlying factors. While DHD and HDI were associated with different predictors, our results point to the crucial role of spiritual-existential factors in the experience of WTHD, identifying these aspects as target points for intervention. This study highlights the importance of a nuanced understanding and communication regarding WTHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1478951526102673","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:47:48Z","timestamp":1778744868000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Beyond the surface: Exploring differing aspects of wishes to hasten death in patients with amyotrophic lateral sclerosis"],"prefix":"10.1017","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1188-8928","authenticated-orcid":false,"given":"Tamara","family":"Thurn","sequence":"first","affiliation":[{"name":"Technical University of Munich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Chi\u00f2","sequence":"additional","affiliation":[{"name":"University of 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